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| N6-CYCLOHEXYLADENOSINE Basic information |
| Product Name: | N6-CYCLOHEXYLADENOSINE | | Synonyms: | CHA;N6-CYCLOHEXYLADENOSINE;N6-CYCLOHEXYLADENOSINE (CHA) SELECTIVE A 1 ADENOSIN;N(sup 6)-cyclohexyladenosine;Cyclohexyladenosine;N-Cyclohexyladenosine;Adenosine, N-cyclohexyl-;N6-Cyclohexyladenosine,CHA | | CAS: | 36396-99-3 | | MF: | C16H23N5O4 | | MW: | 349.38 | | EINECS: | | Product Categories: | | Mol File: | 36396-99-3.mol |
| N6-CYCLOHEXYLADENOSINE Chemical Properties |
| Melting point | 182 - 184°C | | storage temp. | 2-8°C | | solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| WGK Germany | 3 | | HS Code | 29349990 |
| N6-CYCLOHEXYLADENOSINE Usage And Synthesis |
| Description | N6-Cyclohexyladenosine is an adenosine receptor agonist. It selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM). N6-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC25s = 2.4 and 4.2 μg/kg, respectively). N6-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion. N6-Cyclohexyladenosine also decreases locomotor activity in mice (ED50 = 60 μg/kg, i.p.). | | Uses | N6-Cyclohexyladenosine is a derivative of Adenosine (A280400), and is used testing adenosine A1 and A2A receptor activation for pharmaceuticals such as antidepressants. N6-Cyclohexyladenosine also is used as a JAK2 inhibitor, blocking STAT3 signalling in human cancer cells. | | Biochem/physiol Actions | Selective A1 adenosine receptor agonist. |
| N6-CYCLOHEXYLADENOSINE Preparation Products And Raw materials |
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