Product

3-(4-FLUOROBENZOYL)PROPIONIC ACID

CAS No.：366-77-8

Other grades of this product :

3-(4-FLUOROBENZOYL)PROPIONIC ACID Basic information

Product Name:	3-(4-FLUOROBENZOYL)PROPIONIC ACID
Synonyms:	HALOPERIDOL METABOLITE III;LABOTEST-BB LT00233221;3-(4'-FLUOROBENZOYL)PROPIONIC ACID;3-(4-FLUOROBENZOYL)PROPIONIC ACID;4-(4-FLUOROPHENYL)-4-OXOBUTANOIC ACID;4-(4-FLUOROPHENYL)-4-OXOBUTYRIC ACID;AKOS BBS-00006441;4-FLUORO-R-OXO-BENZENEBUTANOIC ACID
CAS:	366-77-8
MF:	C10H9FO3
MW:	196.18
EINECS:	206-679-1
Product Categories:	Aromatic Building Blocks;Aromatic Propionic Acids;Acids & Esters;Fluorine Compounds
Mol File:	366-77-8.mol

3-(4-FLUOROBENZOYL)PROPIONIC ACID Chemical Properties

Melting point	100-102 °C (lit.)
Boiling point	374.4±22.0 °C(Predicted)
density	1.2441 (estimate)
storage temp.	Sealed in dry,Room Temperature
pka	4.50±0.17(Predicted)
form	powder to crystal
color	White to Orange to Green
Water Solubility	Insoluble in water.
BRN	958145
CAS DataBase Reference	366-77-8(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,C,Xi
Risk Statements	36/37/38-20/21/22-22
Safety Statements	36/37/39-26-22-24/25
WGK Germany	3
Hazard Note	Corrosive
HazardClass	IRRITANT
HS Code	29183000

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

3-(4-FLUOROBENZOYL)PROPIONIC ACID Usage And Synthesis

Chemical Properties	beige granular powder
Uses	7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone.
General Description	3-(4-Fluorobenzoyl)propionic acid is a metabolite of haloperidol, a dopamine D2 receptor blocker.

3-(4-FLUOROBENZOYL)PROPIONIC ACID Preparation Products And Raw materials

Raw materials	Succinic anhydride-->Fluorobenzene
Preparation Products	IMAZODAN-->7-FLUORO-1-TETRALONE-->(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

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