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| MPP+ IODIDE Basic information |
| MPP+ IODIDE Chemical Properties |
| Melting point | 166-168 °C | | storage temp. | desiccated | | solubility | 0.1 M HCl: soluble | | form | solid | | color | yellow | | InChIKey | RFDFRDXIIKROAI-UHFFFAOYSA-M |
| MPP+ IODIDE Usage And Synthesis |
| Uses | Dopaminergic neurotoxin; a selective cytostatic agent in small-cell lung cancer cell lines with neuroendocrine properties. | | Uses | MPP+ iodide is an active metabolite of the dopaminergic neurotoxin MPTP. | | General Description | 1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide. | | Biochem/physiol Actions | MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP. |
| MPP+ IODIDE Preparation Products And Raw materials |
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