ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

CAS No.：37178-37-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate Basic information

Product Name:	ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
Synonyms:	O-Ethyl-DOPA;TV-1203;ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate;L-DOPA Ethyl Ester;2(S)-Amino-3-(3,4-dihydroxyphenyl)propionic acid ethyl ester;3,4-Dihydroxy-L-phenylalanine ethyl ester;3-Hydroxy-L-tyrosine ethyl ester;L-Dopa-Et
CAS:	37178-37-3
MF:	C11H15NO4
MW:	225.24
EINECS:
Product Categories:
Mol File:	37178-37-3.mol

ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate Chemical Properties

Boiling point	394.2±37.0 °C(Predicted)
density	1.278±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H2O: ≥12mg/mL at warmed to 60°C
pka	9.67±0.20(Predicted)
form	powder
color	white to tan

Safety Information

Hazard Codes	Xn
Risk Statements	22-36
Safety Statements	26
WGK Germany	3

MSDS Information

ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate Usage And Synthesis

Uses	Antiparkisonian.
Uses	L-Dopa ethyl ester has been used to study the protective effects of piperlongumine (PLG) on rotenone-induced Parkinson disease (PD).
Biochem/physiol Actions	L-Dopa ethyl ester is a prodrug of levodopa that has greater gastric solubility. The drug is rapidly hydrolyzed to levodopa by nonspecific esterases in the gastrointestinal tract. L-Dopa ethyl ester (etilevodopa)-carbidopa treatment was well tolerated but did not demonstrate better efficacy compared with standard levodopa-carbidopa treatment. L-Dopa ethyl ester should have a significant brain penetration following an administration by injection.

ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate Preparation Products And Raw materials

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