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| EC 5.3.4.1 Basic information |
| Product Name: | EC 5.3.4.1 | | Synonyms: | DSBA;EC 5.3.4.1;CONNECTASH(TM) PROTEIN DISULFIDE-ISOMERASE;PROTEIN DISULFIDE ISOMERASE;PDI;THIOL:DISULFIDE INTERCHANGE PROTEIN DSBA;Protein disulfide Isomerase bovine liver;5-aminooxysulfonyl-2,4-dichlorobenzoic acid | | CAS: | 37318-49-3 | | MF: | C7H5Cl2NO5S | | MW: | 0 | | EINECS: | | Product Categories: | enzyme | | Mol File: | Mol File |
| EC 5.3.4.1 Chemical Properties |
| storage temp. | -20°C | | form | lyophilized powder |
| WGK Germany | 3 | | F | 3-10-21 | | HS Code | 3504009000 |
| EC 5.3.4.1 Usage And Synthesis |
| Uses | Protein Disulfide Isomerase from bovine liver has been used:- to study the functional role of PDI in parasite infection and the interaction between macrophage PDI and?L. chagasi
- in the in vitro translation reaction for the generation of disulfide bonds
- in insulin-disulfide reduction assay and peptide binding assay
- as a positive control in thiol-disulfide oxidoreductase activity assay
| | General Description | Protein disulfide isomerase (PDI) from bovine liver is a homodimer with a molecular weight of 107 kDa with the monomer corresponding to 57 kDa. The isoelectric point (pI) is approximately 4.2. The enzyme is a glycoprotein with 12% total carbohydrate content comprising of mannose, galactose, N-acetyl neuraminic acid (NANA) and 2-acetamido-2-deoxyglucose. PDI is an ubiquitous redox chaperone enzyme. It belongs to the, thioredoxin superfamily and is high conserved. | | Biochem/physiol Actions | Protein Disulfide Isomerase (PDI) is mainly located in the endoplasmic reticulum (ER), where it assists in protein-folding and thiol-disulfide exchanges. It aids protein refolding in vitro allowing recombinant proteins to achieve their native state. |
| EC 5.3.4.1 Preparation Products And Raw materials |
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