Other grades of this product :
| KISSPEPTIN-10 Basic information |
| Product Name: | KISSPEPTIN-10 | | Synonyms: | MALIGNANT MELANOMA METASTASIS-SUPPRESSOR KISS-1 (112-121) (HUMAN);METASTIN (HUMAN, 45-54);METASTIN (45-54);METASTIN (45-54) AMIDE, HUMAN;METASTIN (45-54), HUMAN;KISSPEPTIN-13 (4-13) (HUMAN);KISS-1 GENE PRODUCT (HUMAN, 112-121 AMIDE);TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2 | | CAS: | 374675-21-5 | | MF: | C63H83N17O14 | | MW: | 1302.44 | | EINECS: | | Product Categories: | Peptide Receptors | | Mol File: | 374675-21-5.mol |
| KISSPEPTIN-10 Chemical Properties |
| density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | pka | 9.96±0.15(Predicted) | | Water Solubility | Soluble in water at 1mg/ml |
| KISSPEPTIN-10 Usage And Synthesis |
| Description | Metastin (45-54) is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product. It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)). Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM). It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin. | | Uses | Metastin (45-54) amide has been used in progesterone release experiments from MA-10 cells. It has also been used to induce gonadal differentiation in clownfish. | | Uses | Metastin (45-54) is a potent and selective agonist of AXOR12 and hOT7T175. | | General Description | Metastin is also known as kisspeptin 1 (KISS1). It is encoded by KISS1 gene, that is mapped to human chromosome 1q32. Metastin is a tumor suppressor protein, made up of 145 amino acids. The protein fragments contain RFamide motif at the C- terminal end. The encoded protein is expressed in the human hypothalamus, gonads, placenta, liver and pancreas. This novel?peptide?is mainly isolated from the human placenta. | | Biochem/physiol Actions | Metastin functions as a tumor suppressor via inhibiting secondary tumor growth. Activation of KISS1R (KISS1 receptor), upon binding KISS1, enhances intracellular calcium and activates MAPKs, which restricts cell motility and proliferation. Metastin acts as a potential therapeutic target for various cancers including melanoma, thyroid cancer and bladder cancer, squamous cell carcinoma of the esophagus gastric cancer, hepatocellular carcinoma and breast cancer. Metastin has a crucial role in reproduction. It regulates hypothalamic-pituitary-gonadal axis role via controlling gonadotropin-releasing hormone (GnRH) secretion and determines the onset of puberty. Mutation of the gene leads to central precocious puberty (CPP) in male and dysfunction of metastin signaling causes isolated hypogonadotropic hypogonadism (IHH) in humans and mice. Metastin has the ability to enhance the?plasma levels?of?gonadotropins (follicle-stimulating hormone and luteinizing hormone) and stimulate ovulation?in prepubertal female rats. |
| KISSPEPTIN-10 Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye