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| TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE Basic information |
| Product Name: | TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE | | Synonyms: | 1,2-Dimethoxy-3-((E)-2-nitro-vinyl)-benzene;CID 5380390;2,3-dimethoxy-á-nitrostyrene;trans-2,3-dimethoxy-β-nitrostyrene;2,3-DIMETHOXY-SS-NITROSTYRENE;2,3-Dimethoxy-β-nitrostyrene, 98%;1,2-Dimethoxy-3-(2-nitrovinyl)benzene, 2-(2,3-Dimethoxyphenyl)nitroethene;2,3-Dimethoxy-^b-nitrostyrene, 98% | | CAS: | 37630-20-9 | | MF: | C10H11NO4 | | MW: | 209.2 | | EINECS: | | Product Categories: | | Mol File: | 37630-20-9.mol |
| TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE Chemical Properties |
| Melting point | 80-84 °C(lit.) | | storage temp. | room temp | | solubility | DMSO: soluble15mg/mL (clear solution) | | form | powder | | color | faint yellow to dark yellow |
| TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE Usage And Synthesis |
| Biochem/physiol Actions | CID 5380390 (trans-2,3-Dimethoxy-?-nitrostyrene) is a selective inhibitor of Protein Arginine Methyltransferases PRMT1 and PRMT8. PRMT1 is responsible for the majority of arginine methylation in the cell involved in transcription, chromatin modification, and signal transduction. CID 5380390 has an IC50 values of 23 μM for PRMT1, and does not inhibit PRMTs 3, 4, and 6, although it does inhibit PRMT8. The mechanism is believed to involve a specific S-adenosylmethionine (SAM)-binding cysteine present only in the Type I PRMTs PRMT1 and PRMT8 and absent in other SAM-dependent methyltransferases. |
| TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE Preparation Products And Raw materials |
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