Other grades of this product :
| Cholesteryl hemisuccinate Basic information |
| Cholesteryl hemisuccinate Chemical Properties |
| Melting point | 178 °C | | Boiling point | 586.0±43.0 °C(Predicted) | | density | 1.06±0.1 g/cm3(Predicted) | | refractive index | -34 ° (C=2, CHCl3) | | storage temp. | -20°C | | solubility | Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated) | | form | Solid | | pka | 4.40±0.17(Predicted) | | color | White to Off-White | | InChIKey | WLNARFZDISHUGS-BLYFUZNHSA-N | | CAS DataBase Reference | 1510-21-0(CAS DataBase Reference) |
| WGK Germany | 3 | | HS Code | 29171900 |
| Cholesteryl hemisuccinate Usage And Synthesis |
| Description | Cholesteryl hemisuccinate is a cholesterol ester with anticancer activity. It inhibits the growth of murine C1498 myeloid and L1210 lymphocytic leukemia cells when used at concentrations of 50 and 150 μM, respectively. Cholesteryl hemisuccinate acts as an ionizable anionic detergent and is commonly used to stabilize unilamellar vesicles and liposomes. It has also been used as an emulsifying agent in various vesicular drug delivery systems for anticancer drugs, antibiotics, and oligonucleotides and to solubilize various proteins including chemokine receptor 1 as well as erythrocyte ghosts. | | Uses | Cholesteryl Hemisuccinate is an oxidation product of polyunsaturated fatty acid of cholesterol that alters lysosome structure and functions and induces proinflammatory cytokine production in macrophages. | | General Description | Cholesteryl hemisuccinate (CHEMS) is an acidic cholesterol ester. | | Biochem/physiol Actions | CHEMS can help to maintain the stability of dioleoylphosphatidylethanolamine (DOPE). This amphipathic lipid is used in mixtures with dioleoylphosphatidylethanolamine (DOPE) to form ′pH sensitive′ fusogenic vesicles. It can control cell growth. |
| Cholesteryl hemisuccinate Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye