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| S-(4-NITROBENZYL)-6-THIOINOSINE Basic information |
| S-(4-NITROBENZYL)-6-THIOINOSINE Chemical Properties |
| Melting point | 187-190 °C(lit.) | | Boiling point | 770.2±70.0 °C(Predicted) | | density | 1.3904 (rough estimate) | | refractive index | 1.6460 (estimate) | | storage temp. | 2-8°C | | solubility | 0.1 M HCl: slightly soluble | | form | solid | | pka | 13.08±0.70(Predicted) | | color | white | | CAS DataBase Reference | 38048-32-7(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | UO9025000 | | HS Code | 29349990 |
| S-(4-NITROBENZYL)-6-THIOINOSINE Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardio | | Uses | S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents. | | General Description | S-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S6-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport. | | Biological Activity | Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively). | | Biochem/physiol Actions | Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle. |
| S-(4-NITROBENZYL)-6-THIOINOSINE Preparation Products And Raw materials |
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