Other grades of this product :
| (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Basic information |
| Product Name: | (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride | | Synonyms: | R(+)-VERAPAMIL MONOHYDROCHLORIDE MONOHYDRATE;Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (aR)- (9CI);Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (R)-;Dexverapamil monohydrochloride;LU 33925;NSC 632821;Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (alphaR)-;Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]-methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (R)- | | CAS: | 38176-02-2 | | MF: | C27H41ClN2O5 | | MW: | 509.07784 | | EINECS: | 253-810-3 | | Product Categories: | Drug Efflux Pumps;Modulators for MDR/TAP Transporters;Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Multi-Drug Resistance;Pharmaceuticals | | Mol File: | 38176-02-2.mol |
| (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Chemical Properties |
| Melting point | 129-131?C | | storage temp. | Refrigerator | | solubility | H2O: >30mg/mL | | form | powder | | color | white | | optical activity | [α]22/D +9.6°, c = 0.5 in ethanol(lit.) |
| (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Usage And Synthesis |
| Chemical Properties | Colourless solid | | Uses | Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells. | | Uses | R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity. | | Biochem/physiol Actions | Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature. |
| (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Preparation Products And Raw materials |
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methylammonium chloride](/img/38176-02-2.jpg "(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride")
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