Other grades of this product :
| GANAXOLONE Basic information |
| Product Name: | GANAXOLONE | | Synonyms: | 3α-hydroxy-3β-methyl-5α-pregnan-20-one;(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone;(3α,5α)-3-Hydroxy-3-methylpregnan-20-one;1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone | | CAS: | 38398-32-2 | | MF: | C22H36O2 | | MW: | 332.52 | | EINECS: | | Product Categories: | | Mol File: | 38398-32-2.mol |
| GANAXOLONE Chemical Properties |
| Melting point | 190-192° | | alpha | D +103° | | Boiling point | 434.8±18.0 °C(Predicted) | | density | 1.036±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ~4.2 mg/mL | | form | solid | | pka | 15.18±0.70(Predicted) | | color | white |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | TU4384700 |
| GANAXOLONE Usage And Synthesis |
| Description | Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABAA receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABAA receptor complexes containing α1, α2, α3, β2, and γ2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials. | | Uses | Treatment of epilepsy and migraine. | | Uses | Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy. | | Biological Activity | Potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α 2 β 1 γ 2 L , α 3 β 1 γ 2 L and α 1 β 1 γ 2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models. | | Biochem/physiol Actions | Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy. |
| GANAXOLONE Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye