2-CHLORO-2,2-DIFLUOROACETOPHENONE

2-CHLORO-2,2-DIFLUOROACETOPHENONE
  • CAS No.:384-67-8
Other grades of this product :
2-CHLORO-2,2-DIFLUOROACETOPHENONE Basic information
Product Name:2-CHLORO-2,2-DIFLUOROACETOPHENONE
Synonyms:CHLORODIFLUOROACETOPHENONE;alpha,alpha-Difluorophenacyl chloride;2-CHLORO-2,2-DIFLUOROACETOPHENONE;A-CHLORO-A,A-DIFLUOROACETOPHENONE;ALPHA-CHLORO-ALPHA,ALPHA-DIFLUOROACETOPHENONE;ChlorodifluoroMethyl phenyl ketone;2-Chloro-2,2-d;2-chloro-2,2-difluoro-1-phenylethanone
CAS:384-67-8
MF:C8H5ClF2O
MW:190.57
EINECS:621-031-1
Product Categories:Fluorine series
Mol File:384-67-8.mol
2-CHLORO-2,2-DIFLUOROACETOPHENONE Chemical Properties
Melting point 102-103 °C
Boiling point 94-96 °C35 mm Hg(lit.)
density 1.293 g/mL at 25 °C(lit.)
refractive index n20/D 1.497(lit.)
Fp 163 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Difficult to mix.
BRN 2251448
CAS DataBase Reference384-67-8(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37
RIDADR UN 3334
WGK Germany 3
19
Hazard Note Irritant
HS Code 29147000
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
2-CHLORO-2,2-DIFLUOROACETOPHENONE Usage And Synthesis
Uses2-Chloro-2,2-difluoroacetophenone can be used:
  • As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
  • As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
  • As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.
General Description2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds.
2-CHLORO-2,2-DIFLUOROACETOPHENONE Preparation Products And Raw materials

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