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| N-Acetyl-L-cysteinamide Basic information |
| Product Name: | N-Acetyl-L-cysteinamide | | Synonyms: | N-ACETYL-L-CYSTINE;(R)-2-acetaMido-3-MercaptopropanaMide;PropanaMide,2-(acetylaMino)-3-Mercapto-, (2R)-;N-Acetylcysteine amide Synonyms N-Acetyl-L-cysteinamide;(R)- 2-(Acetylamino)-3-mercapto-Propanamide;acetylcysteinamide;AD4;(2R)-2-acetamido-3-sulfanylpropanamide | | CAS: | 38520-57-9 | | MF: | C5H10N2O2S | | MW: | 162.21 | | EINECS: | | Product Categories: | | Mol File: | 38520-57-9.mol |
| N-Acetyl-L-cysteinamide Chemical Properties |
| Melting point | 147-149 °C(Solv: ethanol (64-17-5)) | | Boiling point | 441.0±40.0 °C(Predicted) | | density | 1.226±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | H2O: ≥20mg/mL | | pka | 9.21±0.10(Predicted) | | form | lyophilized powder | | color | white to off-white | | InChIKey | ZLCOWUKVVFVVKA-GDVGLLTNSA-N |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| N-Acetyl-L-cysteinamide Usage And Synthesis |
| Uses | N-acetylcysteine amide has been used:- to protect retinal pigment epithelium (RPE) from oxidative stress
- to show that increased expression of cell adhesion molecule 4 (CADM4) in oligodendrocytes inhibits myelination
- to protect cells from apoptosis induced by shikonin plus erlotinib/gefitinib
- as a component in various culture media
| | Biochem/physiol Actions | N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. The compound readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. In contrast to DTT, AD4 is able to directly reduce intracellularl GSSG to GSH without the involvement of glutathione peroxidase. Such direct thiol exchange might have a protective effect. This compound has a potential in research and exploration for treatment of neurodegeneration, radiation exposure, and other oxidation-mediated disorders. |
| N-Acetyl-L-cysteinamide Preparation Products And Raw materials |
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