Other grades of this product :
| 7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 Basic information |
| Product Name: | 7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 | | Synonyms: | (32)-7-Dehydro Cholesterol-d7 (Major);7-dehydro Cholesterol-d7;7-Dehydrocholesterol-25,26,26,26,27,27,27-d7;Cholesta-5,7-dien-25,26,26,26,27,27,27-d7-3-ol, (3b)-;(3β)-7-Dehydro Cholesterol-d7 (Major);(3β)-7-Dehydro Cholesterol-d7
(See also D229462) | | CAS: | 388622-58-0 | | MF: | C27H44O | | MW: | 384.65 | | EINECS: | | Product Categories: | | Mol File: | 388622-58-0.mol |
| 7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 Chemical Properties |
| storage temp. | -70°C | | form | solid |
| 7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 Usage And Synthesis |
| Uses | 7-dehydrocholesterol-d7 has been used: - as an internal standard: to spike Chlamydomonas CC-125 lipid extract for mass spectroscopy analysis
- in liquid chromatography–mass spectrometry (LC-MS) for cultured cells oxysterol analysis
- to treat and label SRD-1 cell (chinese hamster ovary (CHO) mutant cell-line) for gas chromatography/mass spectrometry (GC/MS) analysis
| | General Description | 7-dehydrocholesterol (7-DHC) is a cholesterol precursor and is localized in basal epidermal keratinocytes. 7DHC on photolysis in the presence of ultraviolet light B generates previtamin D3. The enzyme 7-dehydrocholesterol reductase (DHCR7) catalyzes the reduction of C(7-8) double bond of 7-DHC to cholesterol. 7-dehydrocholesterol-d7 is a deuterated derivative of 7-dehydrocholesterol. | | Biochem/physiol Actions | 7-Dehydrocholesterol (7-DHC) is used as a precursor for microbial vitamin D3 production. Impairment of 7-dehydrocholesterol reductase (DHCR7) functionality leads to 7-DHC accumulation and is implicated in Smith-Lemli-Opitz syndrome (SLOS). |
| 7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 Preparation Products And Raw materials |
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