1-(2-Furoyl)piperazine

CAS No.：40172-95-0

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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1-(2-Furoyl)piperazine Basic information

Product Name:	1-(2-Furoyl)piperazine
Synonyms:	BIO-FARMA BF003584;(FURAN-2-YL)(PIPERAZIN-1-YL)METHANONE;1-(2-FURANYLCARBONYL)-PIPERAZINE;1-(2-FUROYL)PIPERAZINE;AKOS BBS-00003689;AKOS B003992;AKOS BB/0087;N-(2-FUROYL)PIPERAZINE
CAS:	40172-95-0
MF:	C9H12N2O2
MW:	180.2
EINECS:	254-823-7
Product Categories:	BUILDING BLOCKS;API intermediates;Piperidines, Piperidones, Piperazines
Mol File:	40172-95-0.mol

1-(2-Furoyl)piperazine Chemical Properties

Melting point	67-70 °C(lit.)
Boiling point	137-140°C 0,1mm
density	1.1819 (rough estimate)
refractive index	1.5373 (estimate)
Fp	>230 °F
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	Chloroform, Methanol (Slightly)
form	neat
pka	8.37±0.10(Predicted)
color	White to Pale Yellow
Sensitive	Hygroscopic
BRN	880196
Stability:	Very Hygroscopic
CAS DataBase Reference	40172-95-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-24/25
WGK Germany	3
F	10-34
HazardClass	IRRITANT
HS Code	29339900

MSDS Information

Provider	Language
1-(2-Furoyl)piperazine	English
SigmaAldrich	English
ACROS	English
ALFA	English

1-(2-Furoyl)piperazine Usage And Synthesis

Chemical Properties	white to light yellow solid
Uses	2-Furanyl-1-piperazinylmethanone was utilized in the fragment-based design of symmetrical bis-benzimidazole as inhibitors of R67 dihydrofolate reductase.
Uses	2-Furanyl-1-piperazinylmethanone (Terazosin EP Impurity L) was utilized in the fragment-based design of symmetrical bis-benzimidazole as inhibitors of R67 dihydrofolate reductase.
Uses	1-(2-Furoyl)piperazine may be used to synthesize: 2-[4-(2-furoyl) piperazin-1-yl]-4-amino-6-benzyloxy-7-methoxyquinazoline hydrochloride monohydrate 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-7-benzyloxy-6-methoxyquinazoline hydrochloride monohydrate 4-amino-2-[4-(2-furoyl)piperazin-1-yl]-quinazoline hydrochloride 6,7-dimethoxy-2-[4-(2-furoyl)-piperazin-1-yl]quinazoline-4-one hydrate 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(2-furoyl)-piperazine hydrogen oxalate 1-(3,4-dichlorobenzyl)-4-(2-furoyl)-piperazine hydrogen oxalate 4-(9-fluorenyl)-1-(2-furoyl)piperazine 2-[4-(2-furoyl)piperazin-1-yl]-benzimidazole hydrochloride hydrate
Synthesis Reference(s)	Journal of Medicinal Chemistry, 20, p. 146, 1977 DOI: 10.1021/jm00211a031

1-(2-Furoyl)piperazine Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Dichloromethane-->Thionyl chloride-->Toluene-->Triethylamine-->Di-tert-butyl dicarbonate-->Piperazine-->2-Furoic acid
Preparation Products	Prazosin

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