DMEOB

CAS No.：40252-74-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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DMEOB Basic information

Product Name:	DMEOB
Synonyms:	DMEOB;[(3-METHOXYPHENYL)METHYLENE]HYDRAZONE-3-METHOXYBENZALDEHYDE;3-METHOXYBENZALDEHYDE [(3-METHOXYPHENYL)METHYLENE]HYDRAZONE;bis(3-methoxybenzylidene)hydrazine;Benzaldehyde, 3-methoxy-, 2-[(3-methoxyphenyl)methylene]hydrazone
CAS:	40252-74-2
MF:	C16H16N2O2
MW:	268.31
EINECS:
Product Categories:	Glutamate receptor
Mol File:	40252-74-2.mol

DMEOB Chemical Properties

storage temp.	2-8°C
solubility	H₂O: insoluble
form	solid
color	yellow

Safety Information

Hazard Codes	Xi,N
Risk Statements	41-50/53
Safety Statements	26-36/37/39-60-61
RIDADR	UN 3077 9/PG 3
WGK Germany	3

MSDS Information

Provider	Language
SigmaAldrich	English

DMEOB Usage And Synthesis

Uses	DMEOB is a negative allosteric modulator at mGluR-5 (1). These mGlu receptors maintain a modulatory role and act as drug targets for various neurological disorders including depression, schizophrenia and Parkinson’s.
Biological Activity	Negative allosteric modulator of the metabotropic glutamate receptor mGlu 5 ; displays reversible non-competitive inhibition of mGlu 5 -mediated responses (IC 50 = 3 μ M).
Biochem/physiol Actions	Negative allosteric modulator at the metabotropic glutamate receptor mGluR5.

DMEOB Preparation Products And Raw materials

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