Other grades of this product :
| DIHYDROFOLIC ACID Basic information |
| Product Name: | DIHYDROFOLIC ACID | | Synonyms: | Folinic Acid EP Impurity G;Folinic Acid EP Impurity G (7,8-Dihydrofolic Acid);(S)-2-(4-(((2-aMino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid;7,8-Dihydrofolic acid (DHF);Dihydrofolic acid
7,8-Dihydropteroyl-L-glutaMic acid;N-[4-[[(2-aMino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-GlutaMic acid;Folinic Acid Impurity G (7,8-Dihydrofolic Acid);7,8-DIHYDROPTEROYL-L-GLUTAMIC ACID | | CAS: | 4033-27-6 | | MF: | C19H21N7O6 | | MW: | 443.41 | | EINECS: | | Product Categories: | | Mol File: | 4033-27-6.mol |
| DIHYDROFOLIC ACID Chemical Properties |
| Melting point | >160°C (dec.) | | density | 1.69±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | 0.1 M NaOH: 10 mg/mL, slightly hazy, orange | | pka | pKa 1.38(H2O t=25 I=0.10) (Occasionally);3.84(H2O t=25 I=0.10) (Occasionally) | | form | Solid | | color | Light Beige to Beige | | BRN | 69017 | | Stability: | Air Sensitive, Hygroscopic, Temperature Sensitive |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| DIHYDROFOLIC ACID Usage And Synthesis |
| Uses | antidote to methotrexate toxicity | | Uses | Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of
dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF). | | Uses | Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF). | | General Description | Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase. | | Biochem/physiol Actions | Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics). | | Purification Methods | DHFA is best purified by suspending (1g mostly dissolved)) in ice-cold sodium ascorbate (300mL of 10% at pH 6.0, prepared by adjusting the pH of 30g of sodium ascorbate in 150mL of H2O by adding 1N NaOH dropwise using a gla |
| DIHYDROFOLIC ACID Preparation Products And Raw materials |
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