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| GW 3965 HYDROCHLORIDE Basic information |
| Product Name: | GW 3965 HYDROCHLORIDE | | Synonyms: | 3-[3-[n-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride;3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-di…;GW3965 HCl;2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid hydrochloride;GW3965 hydrochloride, >=98%;Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-, hydrochloride;GW3965 HCl Salt;3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneacetic acid hydrochloride | | CAS: | 405911-17-3 | | MF: | C33H31ClF3NO3.HCl | | MW: | 0 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 405911-17-3.mol |
| GW 3965 HYDROCHLORIDE Chemical Properties |
| solubility | DMSO: ≥20mg/mL | | form | powder | | color | white | | InChIKey | NMPUWJFHNOUNQU-UHFFFAOYSA-N |
| Hazard Codes | Xn | | Risk Statements | 22-41 | | Safety Statements | 26-39 | | WGK Germany | 3 |
| GW 3965 HYDROCHLORIDE Usage And Synthesis |
| Uses | GW3965 Hydrochloride, is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ. | | Biochem/physiol Actions | GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively. |
| GW 3965 HYDROCHLORIDE Preparation Products And Raw materials |
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