Other grades of this product :
| CIRAZOLINE HYDROCHLORIDE Basic information |
| Product Name: | CIRAZOLINE HYDROCHLORIDE | | Synonyms: | 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazolium chloride;CIRAZOLINE HYDROCHLORIDE SELECTIVE A1 AD RENOCE;CIRAZOLINE HYDROCHLORIDE;2-[(2-CYCLOPROPYLPHENOXY)METHYL]-4,5-DIHYDRO-1H-IMIDAZOLE HYDROCHLORIDE;2-(2-CYCLOPROPYLPHENOXYMETHYL)IMIDAZOLINE HYDROCHLORIDE;LD-3098;LD 3098 hydrochloride;Cirazoline hydrochlo | | CAS: | 40600-13-3 | | MF: | C13H17ClN2O | | MW: | 252.74 | | EINECS: | 2549953 | | Product Categories: | Adrenoceptor | | Mol File: | 40600-13-3.mol |
| CIRAZOLINE HYDROCHLORIDE Chemical Properties |
| storage temp. | Store at RT | | solubility | H2O: >35 mg/mL | | form | solid | | color | white |
| CIRAZOLINE HYDROCHLORIDE Usage And Synthesis |
| Description | Cirazoline is an α1-adrenergic receptor (α1-AR) agonist (Kis = 120, 960, and 660 nM for recombinant α1A-, α1B-, and α1D-ARs, respectively, in CHO cell membranes). It acts as a full agonist at α1A- and a partial agonist at α1B- and α1D-ARs in vitro (EC50s = 70.7, 79.4, and 239.8 nM, respectively). It also acts as an antagonist at α2-ARs with a pA2 value of 7.56 to inhibit the norepinephrine-induced twitch response in isolated pig ileum. Cirazoline (0.01-1 μg/kg) decreases blood pressure when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats. It enhances spatial memory and reduces depressive- and anxiety-like behavior in mice when administered at a concentration of 10 mg/L in drinking water for 2-9 months. It also enhances performance in the variable delayed response task in aged rhesus monkeys at high doses of 1-10 μg/kg but impairs performance at lower doses of 0.01-1 μg/kg. | | Uses | Cirazoline hydrochloride has been used to activate the α1-noradrenergic receptors and to study the inhibitory effect of neurokinin1 (NK1) antagonists on respiratory activity using the brainstem transverse slice. | | Biological Activity | Selective α 1 agonist. Also available as part of the α 1 -Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™ . | | Biochem/physiol Actions | Cirazoline is a selective α1-adrenoceptor agonist and also a non-selective ligand for the imidazoline binding site. Cirazoline dereases spatial working memory performance in aged monkeys. |
| CIRAZOLINE HYDROCHLORIDE Preparation Products And Raw materials |
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