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| (-)-Bicucullinemethiodide Basic information |
| Product Name: | (-)-Bicucullinemethiodide | | Synonyms: | [R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide;1,3-Dioxolo(4,5-G)isoquinolinium, 5-((6R)-6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (5S)-;1,3-Dioxolo(4,5-G)isoquinolinium, 5-(6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (R-(R*,S*))-;(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide;(-)-Bicuculline methiodide;(-)-Bicuculline methiodide
DISCONTINUED. offer B382505 | | CAS: | 40709-69-1 | | MF: | C21H20INO6 | | MW: | 0 | | EINECS: | | Product Categories: | GABA/Glycine receptor | | Mol File: | 40709-69-1.mol |
| (-)-Bicucullinemethiodide Chemical Properties |
| RTECS | JI4904100 | | storage temp. | Store at RT | | solubility | H2O: soluble10mg/mL, almost clear, greenish-yellow | | form | Pale yellow solid. | | optical activity | [α]/D -117±7°, c = 1 in chloroform | | BRN | 5419649 |
| WGK Germany | 3 | | HazardClass | 6.1 |
| (-)-Bicucullinemethiodide Usage And Synthesis |
| Uses | 1(S),9(R)-(-)-Bicuculline methiodide has been used as a gamma-aminobutyric acid (GABA) antagonist to block inhibition in the semicoronal slices. It has also been used for the preparation of organotypic hippocampal slice cultures (OHSCs). | | General Description | Bicuculline is a phthalide isoquinoline alkaloid, which is extracted from Dicentra cucullaria. It acts as an acetylcholinesterase?inhibitor. Bicuculline inhibits slow afterhyperpolarization (AHP). | | Biological Activity | Methiodide form of classical GABA A receptor antagonist (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels. | | Biochem/physiol Actions | (-)-Bicuculline methiodide is a GABAA receptor antagonist, which acts as a competitive inhibitor of GABA ligand binding to the receptor. |
| (-)-Bicucullinemethiodide Preparation Products And Raw materials |
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