Other grades of this product :
| PD 146176 Basic information |
| Product Name: | PD 146176 | | Synonyms: | 6,11-dihydrothiochromeno[4,3-b]indole;[1]Benzothiopyrano[4,3-b]indole, 6,11-dihydro-;PD146176 (NSC168807);NSC168807 | | CAS: | 4079-26-9 | | MF: | C15H11NS | | MW: | 237.32 | | EINECS: | | Product Categories: | | Mol File: | 4079-26-9.mol |
| PD 146176 Chemical Properties |
| Melting point | 160 °C | | Boiling point | 485.4±24.0 °C(Predicted) | | density | 1.333±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | DMSO: 16 mg/mL, soluble | | form | solid | | pka | 16.17±0.20(Predicted) | | color | cream-colored |
| PD 146176 Usage And Synthesis |
| Description | PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1. It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits and reduces oxidant stress-induced apoptosis in endothelial cells. PD 146176 inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP. In addition, it lacks significant non-specific antioxidant properties. | | Uses | PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue. | | Biological Activity | Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (K i = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC 50 = 0.54 μ M for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo . | | Biochem/physiol Actions | PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme. |
| PD 146176 Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye