Other grades of this product :
| A[5']P5[5']A SODIUM SALT Basic information |
| Product Name: | A[5']P5[5']A SODIUM SALT | | Synonyms: | A[5']P5[5']A SODIUM SALT;P1,P5-DI(ADENOSINE-5') PENTAPHOSPHATE SODIUM SALT;Adenosine 5'-(hexahydrogen pentaphosphate), 5'->5'-ester with adenosine, pentasodium salt;P1,P5-DI(ADENOSINE-5') PENTAPHOSPHATESOD IUM;P1,P5-di(adenosine-5')pentaphosphate pentasodium salt 5H2O;Adenosine-5'-pentaphosphateε-5'-adenosyl α,β,γ,δ,ε-pentasodium salt;A(5′)P5(5′)A;Diadenosine pentaphosphate pentasodium salt | | CAS: | 4097-04-5 | | MF: | C20H24N10Na5O22P5 | | MW: | 1026.28 | | EINECS: | 223-852-7 | | Product Categories: | | Mol File: | 4097-04-5.mol |
| A[5']P5[5']A SODIUM SALT Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: 50 mg/mL | | form | powder | | color | white to white with yellow cast | | BRN | 4949216 |
| A[5']P5[5']A SODIUM SALT Usage And Synthesis |
| Uses | P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt has been used as:- an adenylate kinase (AK) inhibitor in: sarcoma osteogenic (Saos-2) cells
- mitochondrial lysates during ATP synthesis
- tetramethylrhodamine methyl ester (TMRM) based membrane potential assay
- chromoplasts
| | General Description | P1,P5-Di(adenosine-5′) pentaphosphate (Ap5A) is a diadenosine polyphosphate, which has a tail-to-tail dimer structure. Ap5A is synthesized in a twostep process involving the formation of adenosine 5′-tetraphosphate (P4A) from the ATP and trimeta-phosphate (P3). In the second step, P4A is converted to Ap5A. The synthesis of Ap5A requires a pH optimum in the range of 7.5 to 8.5 and is modulated by metal ions. | | Biochem/physiol Actions | A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor. |
| A[5']P5[5']A SODIUM SALT Preparation Products And Raw materials |
|
![A[5']P5[5']A SODIUM SALT](/img/4097-04-5.jpg "A[5']P5[5']A SODIUM SALT")
日本语
한국어
Français
Deutsch
España
Türkiye