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| (S)-(-)-PROPRANOLOL HYDROCHLORIDE Basic information |
| (S)-(-)-PROPRANOLOL HYDROCHLORIDE Chemical Properties |
| Melting point | 193-195 °C(lit.) | | storage temp. | 2-8°C | | solubility | ethanol: 10 mg/mL | | form | powder | | optical activity | [α]25/D 25.5°, c = 1.0 in ethanol(lit.) | | BRN | 3574966 | | InChIKey | ZMRUPTIKESYGQW-UQKRIMTDSA-N | | CAS DataBase Reference | 4199-10-4(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | WGK Germany | 3 |
| (S)-(-)-PROPRANOLOL HYDROCHLORIDE Usage And Synthesis |
| Description | (S)-(-)-Propranolol is the active enantiomer of propranolol, a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. It is also a non-specific serotonin receptor antagonist. Propanolol was one of the first β-adrenergic receptor blockers to be widely used in clinical practice for the treatment of hypertension, angina pectoris, and cardiac ischemia. | | Chemical Properties | (S)-(-)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride | | Uses | active enantiomer, 5-HT1 receptor antagonist | | Uses | The S-enantiomer of Propranolol (P831800). β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II). | | Uses | Antihypertensor;Beta-adrenergic blocking agent | | Biological Activity | More active enantiomer of the β -adrenoceptor antagonist propranolol ((RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride ). | | Biochem/physiol Actions | (S)-(?)-Propranolol hydrochloride is biologically active enantiomer. It acts as β1 receptor antagonist in thalamocortical neurons. (S)-(?)-Propranolol hydrochloride elicits its inhibitory function on the β1 adrenoceptor in trigeminovascular pain pathway and serves as a preventive medicine in migraine. | | Purification Methods | The (+)-salt is the active isomer which blocks isoprenaline tachycardia and is a -adrenergic blocker. [Leclerc et al. Trends Pharmacol Sci 2 18 1981, Howe & Shanks Nature 210 1336 1966.] |
| (S)-(-)-PROPRANOLOL HYDROCHLORIDE Preparation Products And Raw materials |
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