6-NITROVERATRYL CHLOROFORMATE

6-NITROVERATRYL CHLOROFORMATE
  • CAS No.:42855-00-5
Other grades of this product :
6-NITROVERATRYL CHLOROFORMATE Basic information
Product Name:6-NITROVERATRYL CHLOROFORMATE
Synonyms:NVOC CHLORIDE;NVOC-CL;((nitroveratryl)oxy)chlorocarbamate;6-NITROVERATRYL CHLOROFORMATE 97%;6-NITROVERATRYL CHLOROFORMATE;6-NITROVERATRYLOXYCARBONYL CHLORIDE;4,5-DIMETHOXY-2-NITROBENZYL CHLOROFORMATE;Chloroformic acid 6-nitroveratryl ester~4,5-Dimethoxy-2-nitrobenzyl chloroformate~NVOC-Cl
CAS:42855-00-5
MF:C10H10ClNO6
MW:275.64
EINECS:
Product Categories:
Mol File:42855-00-5.mol
6-NITROVERATRYL CHLOROFORMATE Chemical Properties
Melting point 125 °C (dec.)(lit.)
Boiling point 396.4±42.0 °C(Predicted)
density 1.399±0.06 g/cm3(Predicted)
storage temp. 2-8°C
Water Solubility Soluble in methanol, acetone. Reacts with water.
Sensitive Moisture & Light Sensitive
BRN 2389168
Safety Information
Hazard Codes C
Risk Statements 34-37
Safety Statements 26-36/37/39-45
RIDADR UN 3261 8/PG 2
WGK Germany 3
10-21
HazardClass 8
PackingGroup III
HS Code 2918999090
MSDS Information
ProviderLanguage
SigmaAldrich English
6-NITROVERATRYL CHLOROFORMATE Usage And Synthesis
Uses4,5-Dimethoxy-2-nitrobenzyl chloroformate is used as a reagent for protection of amines, for use in N-protection of bases in nucleotide synthesis, photochemical protecting groups in organic synthesis. It is used as pharmaceutical intermediate.
Uses4,5-Dimethoxy-2-nitrobenzyl chloroformate (NVOC-Cl) is a photolabile protecting reagent, commonly used in peptide or nucleotide synthesis to protect amines and hydroxyl groups. General applications are:
  • Preparation of inactive, caged protein conjugates which can be activated by irradiating near-ultraviolet light.
  • Solid-phase synthesis of base-sensitive S-acylthioethyl (SATE)-prooligonucleotides.
  • Modification of surface properties by introducing photocleavable NVOC moiety into chitosan to control cell attachment.
6-NITROVERATRYL CHLOROFORMATE Preparation Products And Raw materials
Raw materials4,5-DIMETHOXY-2-NITROBENZYL ALCOHOL-->Triphosgene-->PHOSGENE

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