Sodium ketoisocaproate

CAS No.：4502-00-5

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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Sodium ketoisocaproate Basic information

Product Name:	Sodium ketoisocaproate
Synonyms:	Sodium ketoisocaproate;SODIUM 4-METHYL-2-OXOVALERATE;SODIUM ALPHA-KETOISOCAPRATE;2-KETOISOCAPROIC ACID SODIUM SALT;2-KETOISOHEXANOIC ACID SODIUM SALT;A-KETOISOCAPROIC ACID, SODIUM SALT;ALPHA-KETOISOCAPROIC ACID SODIUM SALT;4-Methyl-2-oxopentanoic acid monosodium salt
CAS:	4502-00-5
MF:	C6H9NaO3
MW:	152.12
EINECS:	224-816-3
Product Categories:	pharmacetical
Mol File:	4502-00-5.mol

Sodium ketoisocaproate Chemical Properties

Melting point	275 °C (dec.)(lit.)
storage temp.	2-8°C
solubility	Water (Slightly)
form	Solid
color	White to Off-White
JECFA Number	633.1
BRN	4239297
Stability:	Hygroscopic
CAS DataBase Reference	4502-00-5(CAS DataBase Reference)

Safety Information

Safety Statements	24/25-22
WGK Germany	3

MSDS Information

Provider	Language
4-Methyl-2-oxopentanoic acid sodium salt	English
SigmaAldrich	English
ACROS	English

Sodium ketoisocaproate Usage And Synthesis

Occurrence	Reported found in banana, asparagus, cheese, white wine, cocoa, blue cheese and provolone cheese.
Uses	Sodium 4-methyl-2-oxovalerate has been used for quantifying branched-chain keto acids from cell extracts by HPLC-fluorescence method.
Uses	4-Methyl-2-oxovaleric Acid is an α-ketomonocarboxylic acid that triggers insulin release by acting upon receptor sites which differ from those occupied by amino acids. 4-Methyl-2-oxovaleric Acid is an intermediate in the metabolism of Leucine.
Biochem/physiol Actions	α-Ketoisocaproic acid is a leucine metabolite that is known to induce insulin secretion from the βcells of pancreas. Enteral infusion of aα-Ketoisocaproate is found to ameliorate, endotoxemic condition. The resulting ketone bodies obtained from its conversion, might serve as an energy source. Accumulation of α-Ketoisocaproic acid is characterized in branched chain ketoaciduria, which is caused due to the lack of branched chain L-2-keto acid dehydrogenase activity. α-Ketoisocaproic acid causes dissociation in the oxidative phosphorylation reaction and acts as a metabolic inhibitor of α-ketoglutarate dehydrogenase. Thus, leads to a defect in the mitochondrial homeostasis, observed in branched chain ketoaciduria.

Sodium ketoisocaproate Preparation Products And Raw materials

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