2,5-DiMethyl Celecoxib

CAS No.：457639-26-8

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2,5-DiMethyl Celecoxib Basic information

Product Name:	2,5-DiMethyl Celecoxib
Synonyms:	4-[5-(2,5-DiMethylphenyl)-3-(trifluoroMethyl)-1H-pyrazol-1-yl]benzenesulfonaMide;2,5-DiMethyl-celecoxib DMC;2,5-Dimethylcelecoxib 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide;2,5-DiMethyl Celecoxib;4-[5-(2,5-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide;Celecoxib-13;Celecoxib Impurity 42;Celecoxib Impurity K
CAS:	457639-26-8
MF:	C18H16F3N3O2S
MW:	395.4
EINECS:
Product Categories:	Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:	457639-26-8.mol

2,5-DiMethyl Celecoxib Chemical Properties

Melting point	>138°C (dec.)
Boiling point	516.7±60.0 °C(Predicted)
density	1.40±0.1 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: soluble20mg/mL, clear
pka	9.67±0.10(Predicted)
form	powder
color	white to beige

Safety Information

Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3

MSDS Information

2,5-DiMethyl Celecoxib Usage And Synthesis

Uses	A non-cyclooxygenase-2 inhibitor analog of Celecoxib (C251000). The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib.
Uses	2,5-Dimethyl-celecoxib has been used To block the synthesis of prostaglandin E2 and to study effect of transforming growth factor-2 signaling towards cyclooxygenase-2 expression. In an in vitro study to analyze its pro-oxidative capacities in metastatic melanoma/ breast cancer cells. To study its interaction between silymarin on chemically induced osteoarthritis in rats.
Biochem/physiol Actions	Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.

2,5-DiMethyl Celecoxib Preparation Products And Raw materials

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