(R)-(-)-Phenylsuccinic acid

CAS No.：46292-93-7

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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(R)-(-)-Phenylsuccinic acid Basic information

Product Name:	(R)-(-)-Phenylsuccinic acid
Synonyms:	(R)2-Phenylsuccinicacid;(R)-(-)-PHENYLSUCCINIC ACID;(R)-(-)-PHENYLSUCCINIC ACID 99+%;(R)-2-Phenylbutanedioic acid;Butanedioic acid, 2-phenyl-, (2R)-;(R)-(-)-Phenylsuccinic acid >=96.0% (sum of enantiomers, HPLC);(2R)-2-Phenylbutanedioic acid;(2R)-2-Phenylbutanedioicacid>99%ee
CAS:	46292-93-7
MF:	C10H10O4
MW:	194.18
EINECS:
Product Categories:	Miscellaneous;Carboxylic Acids;Chiral Building Blocks;Organic Building Blocks
Mol File:	46292-93-7.mol

(R)-(-)-Phenylsuccinic acid Chemical Properties

Melting point	173-176 °C
alpha	-175 º (c=1%, acetone)
Boiling point	290.62°C (rough estimate)
density	1.2534 (rough estimate)
refractive index	1.5430 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Acetone (Slightly), Methanol (Slightly)
pka	3.60±0.10(Predicted)
form	Solid
color	White to Off-White
optical activity	[α]20/D 175±4°, c = 1% in acetone
BRN	3201702
CAS DataBase Reference	46292-93-7(CAS DataBase Reference)

Safety Information

Safety Statements	22-24/25
WGK Germany	3
HS Code	2917399590

MSDS Information

Provider	Language
SigmaAldrich	English

(R)-(-)-Phenylsuccinic acid Usage And Synthesis

Chemical Properties	almost white fine powder
Uses	(R)-Phenylsuccinic Acid is an intermediate used in the preparation of optically active succinic acid derivatives used as hypoglycemic agents.
Purification Methods	Purify the acids by re-precipitation from alkali and recrystallisation from H2O. [Naps & Johns J Am Chem Soc 62 2450 1940, Fredga & Matell Bull Soc Chim Belg 62 47 1953, Wren & Williams J Chem Soc 109 572 1916.] The racemate [635-51-8] has m 166-168o, 168o after recrystallisation from H2O or MeCN. Its S-benzylisothiuronium salt has m 164-165o (from EtOH) [Griediger & Pedersen Acta Chem Scand 9 1425 1955]. [Beilstein 9 IV 3351.]

(R)-(-)-Phenylsuccinic acid Preparation Products And Raw materials

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