5-Chloroisatoic anhydride
5-Chloroisatoic anhydride
  • CAS No.:4743-17-3
Other grades of this product :
5-Chloroisatoic anhydride Basic information
Product Name:5-Chloroisatoic anhydride
Synonyms:TIMTEC-BB SBB003570;AKOS BBS-00002892;5-CHLOROISATOIC ANHYDRIDE;5-CHLOROISATONIC ANHYDRIDE;6-CHLORO-1,2-DIHYDRO-4 H-3,1-BENZOXAZINE-2,4-DIONE;6-chloro-4h-3,1-benzoxazine-2,4(1h)-dione;5-Chloroisotoic anhydride;6-Chloro-2H-3,1-benzoxazine-2,4(1H)-dione
CAS:4743-17-3
MF:C8H4ClNO3
MW:197.58
EINECS:225-255-7
Product Categories:Benzoxazines;Building Blocks;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
Mol File:4743-17-3.mol
5-Chloroisatoic anhydride Chemical Properties
Melting point 300 °C (dec.) (lit.)
density 1.540±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly)
form Solid
pka9.76±0.20(Predicted)
color Off-White
CAS DataBase Reference4743-17-3(CAS DataBase Reference)
EPA Substance Registry System2H-3,1-Benzoxazine-2,4(1H)-dione, 6-chloro- (4743-17-3)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39
WGK Germany 3
Hazard Note Irritant
HS Code 2934999090
MSDS Information
ProviderLanguage
SigmaAldrich English
5-Chloroisatoic anhydride Usage And Synthesis
Chemical PropertiesWhite powder
Uses5-Chloroisatoic Anhydride was used as a reagent in the synthesis of 2-acetamidobenzamides bearing the 2-phenoxy functionality which display antiproliferative activity against certain tumor cell lines. Also used in the preparation of inhibitors of delta-5 desaturase.
Preparation 5-Chloroisatoic anhydride is prepared from 5-chloro indole (9c) by stirring in a 4:1 mixture of DMF/H2O for 16 h at room temperature. 1 H NMR (DMSO-d6): δ 11.85 (s, br., 1H), 7.96 (dd, J = 0.8, 8.7 Hz, 1H), 7.87 (dd, J = 2.3, 8.7 Hz, 1H), 7.09 (dd, J = 8.8, 0.8 Hz, 1H).
5-Chloroisatoic anhydride Preparation Products And Raw materials
Preparation Products(2-AMINO-5-CHLOROBENZOYL)HYDRAZIDE

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