Product

AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2

CAS No.：475221-20-6

Other grades of this product :

AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Basic information

Product Name:	AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
Synonyms:	ARG-ILE-TYR-LYS-GLY-VAL-ILE-GLN-ALA-ILE-GLN-LYS-SER-ASP-GLU-GLY-HIS-PRO-PHE-ARG-ALA-TYR-LEU-GLU-SER-GLU-VAL-ALA-ILE-SER-GLU-GLU-LEU-VAL-GLN-LYS-TYR-SER-ASN-SER-NH2;AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2;M.W. 4625.11 C206H324N56O65;NEP1-40;NOGO-66 (1-40);NOGO-66 (1-40) ANTAGONIST PEPTIDE;NOGO EXTRACELLULAR PEPTIDE, 1-40;PubChem ID: 90488731
CAS:	475221-20-6
MF:	C206H324N56O65
MW:	4625.11
EINECS:
Product Categories:	Various Peptides
Mol File:	475221-20-6.mol

AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Chemical Properties

storage temp.	-20°C
solubility	H₂O: 1 mg/mL
form	solid
color	white

Safety Information

Safety Statements	22-24/25
WGK Germany	3

MSDS Information

Provider	Language
SigmaAldrich	English

AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Usage And Synthesis

Uses

Nogo-66(1-40) antagonist peptide has been used as a Nogo-66 receptor antagonist peptide:

to study the preliminary therapeutic effect after inhibition of Nogo-A in the cauda equina compression (CEC) model
to determine the effects of Nogo-A/NgR1 on autophagic activation
to study its role in Nogo-B mediated axonal branching using Schwann cells and sensory neurons of mice

Biochem/physiol Actions

Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. Nogo-66 can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). Competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent.

AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Preparation Products And Raw materials

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