(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium

CAS No.：475473-26-8

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Basic information

Product Name:	(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium
Synonyms:	(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium;CORM-3;Ruthenium, tricarbonylchloro(glycinato-κN,κO)-, (OC-6-44)-;Carbon monoxide releasing molecule 3;Tricarbonylchloro(glycinato)ruthenium (II);Tricarbonylchloro(glycinato)ruthenium
CAS:	475473-26-8
MF:	C5H3ClNO5Ru
MW:	293.6
EINECS:
Product Categories:	Inhibitors
Mol File:	475473-26-8.mol

(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Chemical Properties

storage temp.	-20°C
solubility	H2O: soluble20mg/mL, clear
form	powder
color	light yellow to dark yellow

Safety Information

WGK Germany

MSDS Information

(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Usage And Synthesis

Uses

CORM-3 (carbon monoxide (CO) releasing molecule-3) has been used to study its effect on NLRP3 (leucine-rich-repeat-containing receptor, pyrin-domain-containing 3) inflammasome activation via glycolysis in macrophages and also on hyperglycemia-induced IL-1β (interleukin-1 β) production. It has also been used to study its protective function against H₂O₂-induced apoptosis using primary rabbit lens epithelial cells.

Biochem/physiol Actions

CORM-3 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, has recently been found to be an important gaseous signaling mediator in mammalian cells CORM-3 has been shown to have anti-inflammatory and cardioprotective activity.

(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Preparation Products And Raw materials

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