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(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate

CAS No.：476310-60-8

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(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Basic information

Product Name:	(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
Synonyms:	(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate;VO-OHpic trihydrate;VO Ohpic;VO-Ohpic;VO-OHpic (PTEN Inhibitor);VO-OHpic (hydrate);(OC-6-45)-aqua(3-Hydroxy-2-pyridinecarboxylato-kappaN1,kappaO2)[3-(hydroxy-kappaO)-2-pyridinecarboxylato(2-)-kappaO2]oxovanadate(1-) hydrogen trihydrate;VO-OHpic trihydrate >=98% (HPLC), solid
CAS:	476310-60-8
MF:	C12H8N2O7V.3H2O
MW:	397.189
EINECS:
Product Categories:
Mol File:	476310-60-8.mol

(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Chemical Properties

storage temp.	-20°C
solubility	DMSO: >10mg/mL
form	solid
color	gray

Safety Information

WGK Germany

MSDS Information

(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Usage And Synthesis

Uses	VO-?OHPIC Trihydrate is used to inactivate tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (Pten) which induces a respons that opposes tumorigeneis.
Uses	VO-OHpic trihydrate has been used in studying the role of phosphatase and tensin homolog (PTEN) in polycomb repressive complex 2 (PRC2)-mediated apoptosis. It also has been used as a PTEN inhibitor to study the neuroprotective effect of melatonin in amyloid beta (Aβ)-induced neurotoxicity via PTEN pathway.
General Description	VO-OHpic is a vanadium complex. VO-OHpic might act as a possible pro-senescence anti-cancer drug for treating cancers with reduced phosphatase and tensin homolog (PTEN) expression. It blocks cell viability, cell proliferation, colony formation and induced senescence-associated β-galactosidase activity in Hep3B cells.
Biochem/physiol Actions	VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor.

(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Preparation Products And Raw materials

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