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| 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Basic information |
| Product Name: | 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid | | Synonyms: | 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid;3-hydroxykynurenine;Paralysin II;REF DUPL: 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid;REF DUPL: DL-3-Hydroxykynurenine;3-(3-Hydroxyanthraniloyl)alanine;NSC 96400;rac 3-Hydroxy Kynurenine | | CAS: | 484-78-6 | | MF: | C10H12N2O4 | | MW: | 224.21 | | EINECS: | | Product Categories: | | Mol File: | 484-78-6.mol |
| 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Chemical Properties |
| Melting point | 213 °C (decomp) | | Boiling point | 365.61°C (rough estimate) | | density | 1.2995 (rough estimate) | | refractive index | 1.6620 (estimate) | | storage temp. | 2-8°C | | pka | 2.16±0.23(Predicted) |
| 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Usage And Synthesis |
| Uses | 3-Hydroxykynurenine is a metabolite of tryptophan.
ential endogenous neurotoxin. | | Uses | 3-Hydroxy-DL-kynurenine is a tryptophan metabolite. Could be associated with symptoms in Parkinson''s disease. | | Uses | 3-Hydroxy-DL-kynurenine has been used:- as a substrate for the recombinant human kynureninase assay
- as a reference standard in tandem mass spectrometry (MS/MS) analysis
- as a control for quantifying serum 3-Hydroxy-DL-kynurenine levels in diabetic retinopathy patients
| | Definition | ChEBI: A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3. | | General Description | 3-Hydroxy-DL-kynurenine is a tryptophan metabolite with a molecular weight corresponding to 224Da. It is a chromophore or hydrophilic yellow compound present in the lens of the eye. 3-Hydroxy-DL-kynurenine is synthesized from kynurenine?by the action of enzyme kynurenine 3-monooxygenase (KMO). It is metabolized to 3-hydroxyanthranilic acid and xanthurenic acid in the presence of enzymes kynureninase and kynurenine aminotransferases, respectively. | | Biochem/physiol Actions | 3-Hydroxy-DL-kynurenine (3-HKYN) has antioxidant functionality and prevents lipid peroxidation in cerebral cortex. It may modulate synaptic neurotransmission. The levels of 3-HKYN is elevated in Huntington′s disease. However, its role in neurodegenerative diseases is still not understood well. Kynurenine metabolism is linked with glutamatergic neurotransmission and the level of 3-HKYN is linked to the pathophysiology of schizophrenia. |
| 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Preparation Products And Raw materials |
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