2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid

CAS No.：484-78-6

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2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Basic information

Product Name:	2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
Synonyms:	2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid;3-hydroxykynurenine;Paralysin II;REF DUPL: 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid;REF DUPL: DL-3-Hydroxykynurenine;3-(3-Hydroxyanthraniloyl)alanine;NSC 96400;rac 3-Hydroxy Kynurenine
CAS:	484-78-6
MF:	C10H12N2O4
MW:	224.21
EINECS:
Product Categories:
Mol File:	484-78-6.mol

2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Chemical Properties

Melting point	213 °C (decomp)
Boiling point	365.61°C (rough estimate)
density	1.2995 (rough estimate)
refractive index	1.6620 (estimate)
storage temp.	2-8°C
pka	2.16±0.23(Predicted)

Safety Information

WGK Germany

MSDS Information

2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Usage And Synthesis

Uses	3-Hydroxykynurenine is a metabolite of tryptophan. ential endogenous neurotoxin.
Uses	3-Hydroxy-DL-kynurenine is a tryptophan metabolite. Could be associated with symptoms in Parkinson''s disease.
Uses	3-Hydroxy-DL-kynurenine has been used: as a substrate for the recombinant human kynureninase assay as a reference standard in tandem mass spectrometry (MS/MS) analysis as a control for quantifying serum 3-Hydroxy-DL-kynurenine levels in diabetic retinopathy patients
Definition	ChEBI: A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
General Description	3-Hydroxy-DL-kynurenine is a tryptophan metabolite with a molecular weight corresponding to 224Da. It is a chromophore or hydrophilic yellow compound present in the lens of the eye. 3-Hydroxy-DL-kynurenine is synthesized from kynurenine?by the action of enzyme kynurenine 3-monooxygenase (KMO). It is metabolized to 3-hydroxyanthranilic acid and xanthurenic acid in the presence of enzymes kynureninase and kynurenine aminotransferases, respectively.
Biochem/physiol Actions	3-Hydroxy-DL-kynurenine (3-HKYN) has antioxidant functionality and prevents lipid peroxidation in cerebral cortex. It may modulate synaptic neurotransmission. The levels of 3-HKYN is elevated in Huntington′s disease. However, its role in neurodegenerative diseases is still not understood well. Kynurenine metabolism is linked with glutamatergic neurotransmission and the level of 3-HKYN is linked to the pathophysiology of schizophrenia.

2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Preparation Products And Raw materials

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