1-METHOXY-4-NITRONAPHTHALENE

CAS No.：4900-63-4

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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1-METHOXY-4-NITRONAPHTHALENE Basic information

Product Name:	1-METHOXY-4-NITRONAPHTHALENE
Synonyms:	1-METHOXY-4-NITRONAPHTHALENE;4-Methoxy-1-nitronaphthalene;1-Methoxy-4-nitronaphthalene,99%;1-Methoxy-4-nitronaphthalene 99%;1-Methoxy-4-nitronaphthalin;1-Nitro-4-methoxynaphthalene;methyl4-nitronaphthylether;Naphthalene,1-methoxy-4-nitro-
CAS:	4900-63-4
MF:	C11H9NO3
MW:	203.19
EINECS:	225-528-0
Product Categories:	Naphthalene derivatives;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
Mol File:	4900-63-4.mol

1-METHOXY-4-NITRONAPHTHALENE Chemical Properties

Melting point	83-85 °C (lit.)
Boiling point	341.49°C (rough estimate)
density	1.2621 (rough estimate)
refractive index	1.4950 (estimate)
storage temp.	Sealed in dry,Room Temperature

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39
WGK Germany	3

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

1-METHOXY-4-NITRONAPHTHALENE Usage And Synthesis

Chemical Properties	yellow to orange crystalline powder
Uses	1-Methoxy-4-nitronaphthalene is used as a reagent in the synthesis of UMI-77 (U700850); a small molecule inhibitor of Mcl-1 which blocks and attenuates pancreatic cell cancer growth. Also an anticancer agent.
Synthesis Reference(s)	Synthesis, p. 70, 1985 DOI: 10.1055/s-1985-31110
Purification Methods	Purify it by chromatography on silica gel, then recrystallise it from MeOH or EtOH (yellow needles). [Hodgson & Habeshaw J Chem Soc 47 1942, Bunce et al. J Org Chem 52 4214 1987, Beilstein 6 H 616, 6 III 2938.]

1-METHOXY-4-NITRONAPHTHALENE Preparation Products And Raw materials

Raw materials

Naphthalene, 1-Methoxy-2-nitro--->1-Methoxynaphthalene-->4-METHOXY-1-NAPHTHONITRILE-->4-methoxynaphthalene-1-carboxylate-->TETRANITROMETHANE

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