Product

1-METHOXY-4-NITRONAPHTHALENE

CAS No.：4900-63-4

Other grades of this product :

1-METHOXY-4-NITRONAPHTHALENE Basic information

Product Name:	1-METHOXY-4-NITRONAPHTHALENE
Synonyms:	1-METHOXY-4-NITRONAPHTHALENE;4-Methoxy-1-nitronaphthalene;1-Methoxy-4-nitronaphthalene,99%;1-Methoxy-4-nitronaphthalene 99%;1-Methoxy-4-nitronaphthalin;1-Nitro-4-methoxynaphthalene;methyl4-nitronaphthylether;Naphthalene,1-methoxy-4-nitro-
CAS:	4900-63-4
MF:	C11H9NO3
MW:	203.19
EINECS:	225-528-0
Product Categories:	Naphthalene derivatives;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
Mol File:	4900-63-4.mol

1-METHOXY-4-NITRONAPHTHALENE Chemical Properties

Melting point	83-85 °C (lit.)
Boiling point	341.49°C (rough estimate)
density	1.2621 (rough estimate)
refractive index	1.4950 (estimate)
storage temp.	Sealed in dry,Room Temperature

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39
WGK Germany	3

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

1-METHOXY-4-NITRONAPHTHALENE Usage And Synthesis

Chemical Properties	yellow to orange crystalline powder
Uses	1-Methoxy-4-nitronaphthalene is used as a reagent in the synthesis of UMI-77 (U700850); a small molecule inhibitor of Mcl-1 which blocks and attenuates pancreatic cell cancer growth. Also an anticancer agent.
Synthesis Reference(s)	Synthesis, p. 70, 1985 DOI: 10.1055/s-1985-31110
Purification Methods	Purify it by chromatography on silica gel, then recrystallise it from MeOH or EtOH (yellow needles). [Hodgson & Habeshaw J Chem Soc 47 1942, Bunce et al. J Org Chem 52 4214 1987, Beilstein 6 H 616, 6 III 2938.]

1-METHOXY-4-NITRONAPHTHALENE Preparation Products And Raw materials

Raw materials

Naphthalene, 1-Methoxy-2-nitro--->1-Methoxynaphthalene-->4-METHOXY-1-NAPHTHONITRILE-->4-methoxynaphthalene-1-carboxylate-->TETRANITROMETHANE

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