6-DIAZO-5-OXO-L-NORLEUCINE

CAS No.：157-03-9

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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6-DIAZO-5-OXO-L-NORLEUCINE Basic information

Product Name:	6-DIAZO-5-OXO-L-NORLEUCINE
Synonyms:	6-diazo-5-oxo,l-norleucin;6-diazo-5-oxo-l-norleucin;diazo-oxo-norleucine;don(pharmaceutical);6-DIAZO-5-OXO-L-2-AMINOHEXANOIC ACID;6-DIAZO-5-OXO-L-NORLEUCINE;6-DIAZO-5-OXO-NORLEUCINE;L-DON
CAS:	157-03-9
MF:	C6H9N3O3
MW:	171.15
EINECS:
Product Categories:	Antibiotics
Mol File:	157-03-9.mol

6-DIAZO-5-OXO-L-NORLEUCINE Chemical Properties

Melting point	145 °C
Boiling point	301.12°C (rough estimate)
density	1.3994 (rough estimate)
refractive index	1.5800 (estimate)
storage temp.	-20°C
solubility	DMSO (Slightly, Heated, Sonicated), Water (Slightly)
form	crystalline
color	light yellow
Merck	13,3026
BRN	1725815
Stability:	Hygroscopic

Safety Information

Hazard Codes	T
Risk Statements	23/24/25
Safety Statements	36/37/39-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	RC6340000
F	8

MSDS Information

Provider	Language
SigmaAldrich	English

6-DIAZO-5-OXO-L-NORLEUCINE Usage And Synthesis

Chemical Properties	Slightly yellow powder
Uses	6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.
General Description	Chemical structure: amino acid derivatives
Biochem/physiol Actions	DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.
Purification Methods	Crystallise it from EtOH, H2O/EtOH, MeOH, 95% aqueous MeOH or H2O/Me2CO. [DeWald & Moor J Am Chem Soc 80 3944 1958, Dion et al. J Am Chem Soc 78 3075 1956, Beilstein 4 IV 3278.]

6-DIAZO-5-OXO-L-NORLEUCINE Preparation Products And Raw materials

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