Other grades of this product :
| OLOMOUCINE II Basic information |
| Product Name: | OLOMOUCINE II | | Synonyms: | Olomoucine II - CAS 500735-47-7 - Calbiochem;Nsc736738;Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine;2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol;Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]- | | CAS: | 500735-47-7 | | MF: | C19H26N6O2 | | MW: | 370.45 | | EINECS: | | Product Categories: | | Mol File: | 500735-47-7.mol |
| OLOMOUCINE II Chemical Properties |
| density | 1.32 | | storage temp. | −20°C | | solubility | chloroform: 50 mg/mL, soluble | | form | powder |
| OLOMOUCINE II Usage And Synthesis |
| General Description | A cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC50 of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC50 = 50 nM), Roscovitine (Cat. No. 557360; IC50 = 450 nM), Bohemine (Cat. No. 203600; IC50 = 1.1 μM) and Olomoucine (Cat. No. 495620; IC50 = 7.0 μM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC50 = 3.0 μM, 5.3 μM, 6.3 μM, 6.3 μM and 11.1 μM for CEM, MCF7, HOS, G631 and K562, respectively). | | Biochem/physiol Actions | Cell permeable: yes |
| OLOMOUCINE II Preparation Products And Raw materials |
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