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| N-ACETYL-4-BENZOQUINONE IMINE Basic information |
| N-ACETYL-4-BENZOQUINONE IMINE Chemical Properties |
| Melting point | 74-75 | | Boiling point | 255.6±43.0 °C(Predicted) | | density | 1.13±0.1 g/cm3(Predicted) | | storage temp. | -70°C | | solubility | Chloroform (Slightly, Sonicated), DMSO (Slightly) | | form | Solid | | pka | -3.37±0.20(Predicted) | | color | Pale Yellow to Very Dark Red | | Stability: | Temperature, Moisture, Light, and Oxygen Sensitive | | CAS DataBase Reference | 50700-49-7 |
| WGK Germany | 3 | | RTECS | AC6960000 | | HS Code | 2902110000 | | Toxicity | LD50 i.p. in male BALB/c mice: 20 mg/kg (Dahlin, Nelson) |
| N-ACETYL-4-BENZOQUINONE IMINE Usage And Synthesis |
| Description | N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis. | | Chemical Properties | Yellow Crystalline Solid | | Uses | A toxic metabolite of Acetaminophen, which reacts with serum proteins | | Uses | A toxic metabolite of Acetaminophen (A161220), which reacts with serum proteins. | | Uses | Reactant involved in:• ;Redox reactions1• ;Hydrohalogenation2• ;pH dependent reactions: in acidic media it is hydrolyzed, hydroxylated in alkaline media, and dimerized at intermediate pHs3• ;Mediation of acetaminophen hepatotoxicity4• ;Studies to identify the utility of acetaminophen for treating autoimmune disorders5 | | Uses | N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis. |
| N-ACETYL-4-BENZOQUINONE IMINE Preparation Products And Raw materials |
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