Product

DL-BUTHIONINE-[S,R]-SULFOXIMINE

CAS No.：5072-26-4

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DL-BUTHIONINE-[S,R]-SULFOXIMINE Basic information

Product Name:	DL-BUTHIONINE-[S,R]-SULFOXIMINE
Synonyms:	DL-BUTHIONINE (R,S)-SULFOXIMINE;DL-BUTHIONINE-[S,R]-SULFOXIMINE;DL-BUTHIONINE (S,R)-SULPHOXIME;DL-BUTHIONINE-SULFOXIMINE;2-amino-4-(s-butylsulfonimidoyl)-butanoicaci;2-amino-4-(s-butylsulfonimidoyl)butanoicacid;buthioninesulfoxamine;buthioninesulfoximine
CAS:	5072-26-4
MF:	C8H18N2O3S
MW:	222.31
EINECS:	628-045-7
Product Categories:	Glutathione S-Transferase Agents;Sulfur & Selenium Compounds;D to;Drug and Xenobiotic Metabolism;Enzyme Inhibitors by Enzyme;Fusarinine -C OrnithinesteraseMulti-Drug Resistance and Drug Metabolism;Substrates, Inducers, Inhibitors
Mol File:	5072-26-4.mol

DL-BUTHIONINE-[S,R]-SULFOXIMINE Chemical Properties

Melting point	215 °C (dec.)(lit.)
Boiling point	382.3±52.0 °C(Predicted)
density	1.29±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL, clear, colorless
form	Fluffy Powder
color	White
Merck	13,1520
BRN	2367136
CAS DataBase Reference	5072-26-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	EK7713435
F	10
HS Code	29309090

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English

DL-BUTHIONINE-[S,R]-SULFOXIMINE Usage And Synthesis

Chemical Properties	White Crystalline Solid
Uses	A potent and specific inhibitor of alpha-glutamyl cysteine synthetase
Uses	Biological tool for depletion of glutathione.
Uses	DL-Buthionine-sulfoximine is suitable for use to: examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells investigate the effect of BSO on development of bovine embryos inhibit GSH in several studies investigate the effect of GSH synthesis on oocyte maturation It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH
Definition	ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
General Description	DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.
Biochem/physiol Actions	DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).

DL-BUTHIONINE-[S,R]-SULFOXIMINE Preparation Products And Raw materials

Preparation Products

Ethyl 5-[3-(4,6-dimethoxy pyrimidyl-2-yl)ureido]methylpyrazolyl-4-carboxylic ester

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