Other grades of this product :
| IRAK-1/4 INHIBITOR I Basic information |
| Product Name: | IRAK-1/4 INHIBITOR I | | Synonyms: | 3-Nitro-N-(1-(2-morpholin-4-ylethyl)-1H-benzimidazol-2-yl)benzamide;BenzaMide, N-[1-[2-(4-Morpholinyl)ethyl]-1H-benziMidazol-2-yl]-3-nitro-;Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor;InSolution? Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor;IIRAK-1-4 Inhibitor I;1-(2-(4-Morpholinyl)ethyl)-2-(3-nitrobenzoylamino)benzimidazole;N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole;IRAK-1/4 INHIBITOR I | | CAS: | 509093-47-4 | | MF: | C20H21N5O4 | | MW: | 395.41 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 509093-47-4.mol |
| IRAK-1/4 INHIBITOR I Chemical Properties |
| density | 1.40 | | storage temp. | 2-8°C | | solubility | DMSO: ≥5mg/mL | | form | Yellow crystalline solid | | pka | 11.54±0.43(Predicted) | | color | off-white to light yellow |
| IRAK-1/4 INHIBITOR I Usage And Synthesis |
| Uses | IRAK-1/4 Inhibitor (interleukin-1 receptor-associated kinases) are important mediators in signal transduction of TIR family members. This regulation protects against the development of cancers and other diseases. | | Uses | IRAK-1/4 inhibitor I has been used in various studies to inhibit IRAK1 in hepatoma cell lines and head and neck squamous cell carcinoma (HNSCC) cell lines. | | Biological Activity | irak-1-4 inhibitor i is an inhibitor of both irak-1 and irak-4 with ic50 values of 0.3μm and 0.2μm , respectively [1].il-1 receptor-associated kinases play important roles in signal transduction. there are totally four members of the iraks, they are irak-1, irak-2, irak-m and irak-4. irak-4 can activate nf-κb and mapk pathways and it is shown that the inhibition of irak-4 can be an anti-inflammatory therapy. irak-1-4 inhibitor i is an analog of an initial irak-4 inhibitor hit, which is screened out from a small molecule li brary against irak-4. with the less basic n-ethylenemorpholine moiety, irak-1-4 inhibitor i has a higher potency than other analogs. additionally, it does not show any cytotoxicity in a 72 h proliferation assay in hela cells(ed50 >30μm) [1]. | | Biochem/physiol Actions | IRAK1 overexpression leads to the development of head and neck squamous cell carcinoma (HNSCC). Therefore, IRAK-1/4 inhibitor I might be a potential therapeutic for HNSCC tumors. Various experimental studies states that IRAK-1/4 inhibitor might have a potential to exhibit?inhibitory effects on the nuclear factor (NF)-κB signaling pathway. | | references | [1] jay p. powers, shyun li, juan c. jaen, jinqian liu, nigel p. c. walker, zhulun wang and holger wesche. discovery and initial sar of inhibitors of interleukin-1 receptor-associated kinase-4. bioorganic & medicinal chemistry letters. 2006, 16: 2842–2845. |
| IRAK-1/4 INHIBITOR I Preparation Products And Raw materials |
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