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| 3,4-DICHLOROISOCOUMARIN Basic information |
| Product Name: | 3,4-DICHLOROISOCOUMARIN | | Synonyms: | 3,4-dci;3,4-DICHLORO-2-BENZOPYRAN-1-ONE;3,4-DICHLOROISOCOUMARIN;3,4-dichloroisochromen-1-one;3,4-dichloro-1H-isochroMen-1-one;3,4-DCI, 3,4-Dichloro-2-benzopyran-1-one;3,4-Dichloroisocoumarin - CAS 51050-59-0 - Calbiochem;1H-2-Benzopyran-1-one, 3,4-dichloro- | | CAS: | 51050-59-0 | | MF: | C9H4Cl2O2 | | MW: | 215.03 | | EINECS: | | Product Categories: | | Mol File: | 51050-59-0.mol |
| 3,4-DICHLOROISOCOUMARIN Chemical Properties |
| Boiling point | 304.7±42.0 °C(Predicted) | | density | 1.53±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMF or DMSO at a concentration of 10mM | | form | White lyophilized solid | | BRN | 6802625 |
| Hazard Codes | T | | Risk Statements | 25-36/37/38 | | Safety Statements | 26-36 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | HazardClass | 6.1 |
| 3,4-DICHLOROISOCOUMARIN Usage And Synthesis |
| Description | 3,4-Dichloroisocoumarin (3,4-DCI) is a serine protease inhibitor. It completely inhibits enzyme activity of 24 serine proteases including human leukocyte elastase, thrombin, plasmin, Factor Xa, and Factor XIIa in vitro. 3,4-DCI stimulates caseinolytic activity of bovine pituitary multicatalytic proteinase complex (MPC) by inducing a conformational change in the MPC that exposes the caseinolytic active site. It has been used to functionally characterize the catalytic activities of multiple proteases including rat liver MPC and extracellular lipase. | | Uses | Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors. | | Uses | Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors. It is an inhibitor of Chymotrypsin and Trypsin. ,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. | | General Description | A potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards β-lactamases. Effective at concentrations ranging from 5-100 μM. | | Biochem/physiol Actions | Product does not compete with ATP. |
| 3,4-DICHLOROISOCOUMARIN Preparation Products And Raw materials |
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