8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE

CAS No.：51116-01-9

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8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Basic information

Product Name:	8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
Synonyms:	8-bromoguanosine-3’,5’-cyclicmonophosphate(8-br-cgmp),sodiumsalt,;8-bromoguanosine 3:5-cyclic*monophosphate sodiu;8-Bromoguanosine-3,5-cyclomonophosphate sodium salt;Guanosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate), monosodium salt;8-BROMOGUANOSINE 3':5'-CYCLICMONOPHOSPHA TE SODIUM;8-BROMO-CGMP SODIUM SALT 8-BROMOGUANOSIN E-3',5;GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE, 8-BROMO-, SODIUM SALT;BR-CGMP, NA
CAS:	51116-01-9
MF:	C10H10BrN5O7P.Na
MW:	446.08
EINECS:	256-993-8
Product Categories:	Cyclic Nucleotide related;Cyclic Nucleotide Metabolism;Cyclic Nucleotides and AnalogsSerine/Threonine Kinase Biology;G Proteins and Cyclic Nucleotides;Protein Kinase G (PKG);Serine/Threonine Kinase Activators
Mol File:	51116-01-9.mol

8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Chemical Properties

storage temp.	-20°C
solubility	H₂O: 100 mg/mL
form	powder

Safety Information

WGK Germany	3
F	10-21
HS Code	29349990

MSDS Information

Provider	Language
SigmaAldrich	English

8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Usage And Synthesis

Description	8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase. At 1 μM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.
Chemical Properties	White powder
Uses	8-bromo-cGMP activates cGMP-dependent protein kinase. It can also inhibit acetylcholine-induced increases in intracellular calcium concentrations.
Biological Activity	Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1 α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro .

8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Preparation Products And Raw materials

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