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| N-T-BOC-PYRROLE Basic information |
| N-T-BOC-PYRROLE Chemical Properties |
| Boiling point | 91-92 °C20 mm Hg(lit.) | | density | 1 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.4685(lit.) | | Fp | 167 °F | | storage temp. | Sealed in dry,Room Temperature | | solubility | Acetonitrile, Dichloromethane, Ethyl Acetate, Methanol, Tetrahydrofuran | | form | Solution | | pka | -6.10±0.70(Predicted) | | color | Colorless to yellow | | InChIKey | IZPYBIJFRFWRPR-UHFFFAOYSA-N |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | HS Code | 2933998090 |
| N-T-BOC-PYRROLE Usage And Synthesis |
| Chemical Properties | Colorless liquid | | Uses | Pyrrole-1-carboxylic Acid tert-Butyl Ester is an intermediate in the synthesis of pyrrole derived anti-cancer Agent. | | Uses | N-Boc-pyrrole was used in the synthesis of 1-(tert-butoxycarbonyl)-1H-pyrrol-2-ylboronic acid by treating with n-BuLi and subsequent reaction with trimethyl borate.It may be used as starting material in the synthesis of the following:- tropane drivatives
- N-boc-2-(4-methoxyphenyl)pyrrole
- N-boc-pyrrol-2-ylboronic acid
| | Synthesis Reference(s) | The Journal of Organic Chemistry, 31, p. 764, 1966 DOI: 10.1021/jo01341a027 | | General Description | N-Boc-pyrrole is an N-protected pyrrole. It undergoes Diels–Alder reaction with enantiomerically pure allene-1,3-dicarboxylates to form endo-adducts with retention in configurations at two newly generated stereogenic centers. It also undergoes cyclopropanation with methyl phenyldiazoacetate to form both monocyclopropane and dicyclopropane. Its Ir-catalyzed C-H borylation followed by cross coupling with 3-chlorothiophene to form biheterocycle has been reported. |
| N-T-BOC-PYRROLE Preparation Products And Raw materials |
| Raw materials | 1H-Pyrrole-1-carboxylic acid, 2-(tributylstannyl)-, 1,1-dimethylethyl ester-->1H-Pyrrole-1-carboxylic acid, 2-(4-methoxyphenyl)-, 1,1-dimethylethyl ester-->N-Boc-pyrroline-->ISOPROPYLLITHIUM-->2-[(4-Methylphenyl)sulfonyl]-7-azabicyclo[2.2.1]hepta-2,5-diene-7-carboxylic acid tert-butyl ester-->TERT-BUTYL N-ALLYLCARBAMATE-->3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane-->Pyrrole-->Di-tert-butyl dicarbonate-->Crotonaldehyde | | Preparation Products | Isoxazole, 3-(2,4,6-trimethylphenyl)--->3-Phenylisoxazole |
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