Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-

CAS No.：5184-64-5

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Basic information

Product Name:	Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
Synonyms:	Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-;1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene;MESITYL P-TOLYL SULFONE;ESI-05;ESI-05 (ESI05);1,3,5-trimethyl-2-tosylbenzene;NSC 116966;ESI-05 >=98% (HPLC)
CAS:	5184-64-5
MF:	C16H18O2S
MW:	274.38
EINECS:
Product Categories:
Mol File:	5184-64-5.mol

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Chemical Properties

Melting point	119-120 °C
Boiling point	426.7±45.0 °C(Predicted)
density	1.129±0.06 g/cm3(Predicted)
storage temp.	room temp
form	powder
color	white to beige

Safety Information

MSDS Information

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Usage And Synthesis

Uses

ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury.

Biochem/physiol Actions

ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants.

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Preparation Products And Raw materials

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