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| Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Basic information |
| Product Name: | Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- | | Synonyms: | Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-;1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene;MESITYL P-TOLYL SULFONE;ESI-05;ESI-05
(ESI05);1,3,5-trimethyl-2-tosylbenzene;NSC 116966;ESI-05 >=98% (HPLC) | | CAS: | 5184-64-5 | | MF: | C16H18O2S | | MW: | 274.38 | | EINECS: | | Product Categories: | | Mol File: | 5184-64-5.mol |
| Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Chemical Properties |
| Melting point | 119-120 °C | | Boiling point | 426.7±45.0 °C(Predicted) | | density | 1.129±0.06 g/cm3(Predicted) | | storage temp. | room temp | | form | powder | | color | white to beige |
| Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Usage And Synthesis |
| Uses | ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury. | | Biochem/physiol Actions | ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants. |
| Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Preparation Products And Raw materials |
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![Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-](/img/5184-64-5.jpg "Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-")
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