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| 7-(2-HYDROXYETHYL)THEOPHYLLINE Basic information |
| 7-(2-HYDROXYETHYL)THEOPHYLLINE Chemical Properties |
| Melting point | 163°C | | Boiling point | 365.61°C (rough estimate) | | density | 1.3055 (rough estimate) | | refractive index | 1.6300 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | H2O: Solutions may be stored for several days at 4°C.soluble | | pka | 14.48±0.10(Predicted) | | form | solid | | color | white | | Water Solubility | 2.991g/L(temperature not stated) | | Merck | 14,3878 | | CAS DataBase Reference | 519-37-9(CAS DataBase Reference) |
| 7-(2-HYDROXYETHYL)THEOPHYLLINE Usage And Synthesis |
| Chemical Properties | White Solid | | Originator | Duolip,Merckle,W. Germany,1981 | | Uses | An inhibitor of 3’,5’-Cyclic Nucleotide Phosphodiesterase. Therapeutically, this compound has diuretic, muscle relaxant, bronchial dilation and CNS stimulant activities. | | Uses | Useful synthetic intermediate in the preparation of 7-substituted xanthines. | | Uses | Cardiac analeptic;Phosphodiesterase inhibitor | | Manufacturing Process | 107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol)
7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They
were heated together for 15 hours in a water separator following the addition
of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute
sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated
in a rotary evaporator.The residue was then crystallized from isopropanol, yielding 58.0 g (55%
yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The
compound had a melting point of 131°C to 132°C. | | Therapeutic Function | Antihyperlipidemic | | Biochem/physiol Actions | Pharmacological profile similar to theophylline. |
| 7-(2-HYDROXYETHYL)THEOPHYLLINE Preparation Products And Raw materials |
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