O-DESMETHYLNAPROXEN

CAS No.：52079-10-4

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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O-DESMETHYLNAPROXEN Basic information

Product Name:	O-DESMETHYLNAPROXEN
Synonyms:	Naproxen Impurity 1（Naproxen EP Impurity A）;(s)-6-hydroxy-α-methyl-2-naphthaleneacetic acid;(aS)-6-Hydroxy-α-methyl-2-naphthaleneacetic Acid;(S)-2-(6-Hydroxy-2-naphthyl)propionic Acid;(S)-6-Demethylnaproxen;(S)-6-O-Desmethylnaproxen;(S)-O-Desmethyl Naproxen;(aS)-6-Hydroxy-a-methyl-2-naphthaleneacetic Acid
CAS:	52079-10-4
MF:	C13H12O3
MW:	216.23
EINECS:
Product Categories:	Intermediates & Fine Chemicals;Metabolites & Impurities;Chiral Reagents;Pharmaceuticals
Mol File:	52079-10-4.mol

O-DESMETHYLNAPROXEN Chemical Properties

Melting point	182-183 °C
Boiling point	432.1±20.0 °C(Predicted)
density	1.297±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	4.87±0.30(Predicted)
form	neat
color	white
BRN	8838512
CAS DataBase Reference	52079-10-4

Safety Information

Hazard Codes	Xn,N
Risk Statements	22-43-50/53
Safety Statements	36/37-60-61
RIDADR	UN 3077 9/PG 3
WGK Germany	3

MSDS Information

O-DESMETHYLNAPROXEN Usage And Synthesis

Chemical Properties	Off-Whie to Pale Pink Solid
Uses	A metabolite of Naproxen
Uses	O-Desmethylnaproxen can be used for assaying naproxen metabolites.
Definition	ChEBI: A member of the class of naphthols that is naproxen in which the 6-methoxy group has been demethylated.
Biochem/physiol Actions	CYP2C9 metabolite of naproxen

O-DESMETHYLNAPROXEN Preparation Products And Raw materials

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