1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride

CAS No.：52605-52-4

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Basic information

Product Name:	1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride
Synonyms:	CCP HCL;LABOTEST-BB LT00138222;1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochlorid;Trazodone BP IMP F;Trazodone EP Impurity F;1-(3-CHLOROPHENY)-4-(3-CHLOROPROPYL) PIPERAZINE HYDROCHLORIDE;1-(3-CHLOROPHENYL)-4-(3-CHLOROPROPYL) PIPERAZINE HCL;1-[4-(3-Chlorophenyl)piperazin-1-yl]-3-chloropropane Hydrochloride
CAS:	52605-52-4
MF:	C13H19Cl3N2
MW:	309.66
EINECS:	258-038-0
Product Categories:	Building Blocks;Halogenated Heterocycles;Piperidines, Piperidones, Piperazines;Piperazine derivates;Heterocyclic Building Blocks;Piperazines;Aromatics;Heterocycles;C12 to C14;Building Blocks;C13;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;PiperazinesHeterocyclic Building Blocks;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	52605-52-4.mol

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Chemical Properties

Melting point	198-203 °C(lit.)
Boiling point	147℃[at 101 325 Pa]
vapor pressure	0Pa at 25℃
storage temp.	2-8°C
form	powder to crystal
color	White to Light yellow
Water Solubility	3.9g/L at 28℃
InChIKey	JVLRNANYLVRULL-UHFFFAOYSA-N
LogP	0.301 at 28℃
CAS DataBase Reference	52605-52-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-20/21/22
Safety Statements	26-37/39-24/25
WGK Germany	3
F	10-21
HS Code	2933599550

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Usage And Synthesis

Chemical Properties	Off-White Solid
Uses	1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride is an arylpiperazine compound which is an important intermediate in the preparation of various pharmaceuticals, such as Trazodone (T718500), used to treat depression and post-traumatic stress.
General Description	1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride is present as impurity in nefazodone hydrochloride (pharmaceutical formulation). Synthesis of 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride is reported.
Flammability and Explosibility	Notclassified

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Hydrochloric acid-->Acetone-->Diethanolamine-->1-Bromo-3-chloropropane-->3-Chloroaniline-->3-chloropropanal-->1-(3-Chlorophenyl)piperazine hydrochloride

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