5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID

CAS No.：5262-10-2

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID Basic information

Product Name:	5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID
Synonyms:	Aspartame Impurity 1（Aspartame EP Impurity A）;2-[(2S,5S)-3,6-dioxo-5-(phenylmethyl)piperazin-2-yl]acetic acid;2-[(2S,5S)-3,6-dioxo-5-(phenylmethyl)piperazin-2-yl]ethanoic acid;2-[(2S,5S)-5-(benzyl)-3,6-diketo-piperazin-2-yl]acetic acid;AspartaMe Related CoMpound A;(2S,5S)-5-Benzyl-3,6-dioxo-2-piperazineacetic Acid;Aspartame Related Compound A (25 mg) (5-Benzyl-3,6-dioxo-2-piperazineacetic Acid);(2S,5S)-3,6-Dioxo-5-(phenylMethyl)-2-piperazineacetic Acid
CAS:	5262-10-2
MF:	C13H14N2O4
MW:	262.26
EINECS:	226-075-1
Product Categories:	Aromatics;Heterocycles;Chiral Building Blocks;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocyclic Building Blocks;Piperazines
Mol File:	5262-10-2.mol

5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID Chemical Properties

Melting point	270-272 °C(lit.)
Boiling point	667.4±40.0 °C(Predicted)
density	1.298±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Acetic Acid (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Very Sligh
pka	4.02±0.10(Predicted)
form	neat
color	White to Off-White
optical activity	[α]20/D 9.0°, c = 0.9 in acetic acid

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HS Code	2933599550

MSDS Information

Provider	Language
SigmaAldrich	English

5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID Usage And Synthesis

Chemical Properties	White Solid
Uses	The diketopiperazine impurity of the sweetening agent Aspartame (A790015). It is also found in in processed cocoa powder.
Uses	(2S,5S)-5-Benzyl-3,6-dioxo-2-piperazineacetic Acid (Aspartame EP Impurity A) is the diketopiperazine impurity of the sweetening agent Aspartame (A790015). It is also found in in processed cocoa powder.
General Description	(2S-cis)-(-)-5-Benzyl-3,6-dioxo-2-piperazineacetic acid is a piperazine scaffold that can be used to construct biologically active compounds with therapeutic applications.

5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID Preparation Products And Raw materials

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