N-(2-Aminophenyl)-N'-phenylheptanediamide

CAS No.：537034-15-4

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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N-(2-Aminophenyl)-N'-phenylheptanediamide Basic information

Product Name:	N-(2-Aminophenyl)-N'-phenylheptanediamide
Synonyms:	N-(2-Aminophenyl)-N'-phenylheptanediamide;N1-(2-AMinophenyl)-N7-phenylheptanediaMide;NKL 22;HDAC inhibitor IV;Histone Deacetylase Inhibitor IV;HDACi-4b;HISTONE DEACETYLASE INHIBITOR IV;NKL22;NKL-22;NKL 22;NKL 22, >98%
CAS:	537034-15-4
MF:	C19H23N3O2
MW:	325.4
EINECS:
Product Categories:	Amines;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	537034-15-4.mol

N-(2-Aminophenyl)-N'-phenylheptanediamide Chemical Properties

Melting point	159-161°C
Boiling point	627.9±40.0 °C(Predicted)
density	1.212±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMSO, Methanol
form	Beige solid
pka	14?+-.0.70(Predicted)
color	Off-White to Pale Beige

Safety Information

MSDS Information

N-(2-Aminophenyl)-N'-phenylheptanediamide Usage And Synthesis

Chemical Properties	Off-White Solid
Uses	Histone deacetylase inhibitor IV. A cell-permeable pimeloylanilide compound that acts as a FXN-(frataxin gene) specific HDAC inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedrich’s ataxia) cells due to hypoacetylation of histones H3 and H4.
General Description	A cell-permeable pimeloylanilide compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedreich′s ataxia) cells (~3-fold increase of FXN mRNA at 5 μM in primary FRDA lymphocytes and ~3-fold frataxin expression in FRDA cell line at 2.5 μM) due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K5 and H4K12, without significant changes in acetylation at H3K9, H4K8 and H4K16. In comparison, Trichostatin-A (Cat. No. 647925 and 647926) and SAHA, two other commonly used HDAC inhibitors, exhibit no effect on FXN transcription.
Biochem/physiol Actions	Cell permeable: yes

N-(2-Aminophenyl)-N'-phenylheptanediamide Preparation Products And Raw materials

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