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| FLECAINIDE ACETATE Basic information |
| Product Name: | FLECAINIDE ACETATE | | Synonyms: | 2,5-bis-(2,2,2-trifluoroethoxy)-n-(2-piperidinylmethyl)benzamideacetate;n-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamidemonoacetate;n-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-benzamidmonoacetate;r-818;N-(2-PIPERIDYLMETHYL)-2,5-BIS-(2,2,2-TRIFLUOROETHOXY)BENZAMIDE ACETATE;N-[2-PIPERIDYLMETHYL]-2,5-BIS-[2,2,2-TRIFLUOROETHOXY]BENZAMIDE ACETATE SALT;FLECAINIDE ACETATE;FLECAINIDE ACETATE SALT | | CAS: | 54143-56-5 | | MF: | C19H24F6N2O5 | | MW: | 474.39 | | EINECS: | 258-997-5 | | Product Categories: | Organics | | Mol File: | 54143-56-5.mol |
| FLECAINIDE ACETATE Chemical Properties |
| Melting point | 145-147℃ | | storage temp. | 2-8°C | | solubility | Soluble in water and in anhydrous ethanol. It is freely soluble in dilute acetic acid and practically insoluble in dilute hydrochloric acid. | | form | neat | | color | White | | Water Solubility | Soluble in dilute acetic acid, dimethyl sulfoxide, ethanol, methanol and water. | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month. |
| FLECAINIDE ACETATE Usage And Synthesis |
| Description | Flecainide acetate (54143-56-5) is an open Na+?channel blocker that inhibits fast Na+?current in cardiac muscle in a use- and concentration-dependent manner.1?Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG potassium channels at clinically relevant concentrations.4 | | Chemical Properties | White or almost white, very hygroscopic, crystalline powder. | | Uses | Class I antiarrhythmic. | | Uses | Flecainide acetate is used as a sodium channel blocker and as an anti-arrhythmic. In general, it is used to regulate heartbeats of the upper heart and lower heart chambers. It can also be used to slow down an overactive heart. It is also useful in the treatment of ventricular tachycardias and ventricular arrhythmias. | | Definition | ChEBI: An acetate salt obtained by combining flecainide with one molar equivalent of acetic acid. An antiarrhythmic agent used to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart). | | Brand name | Tambocor
(3M Pharmaceuticals). | | General Description | Flecainide acetate, N-(2-piperidinylmethyl)-2,5-bis (2,2,2-trifluoroethoxy)benzamide monoacetate(Tambocor), is a class IC antiarrhythmic drug withlocal anesthetic activity; it is a chemical derivative of benzamide.The drug undergoes biotransformation, forming ameta-O-dealkylated compound, whose antiarrhythmic propertiesare half as potent as those of the parent drug, and ameta-O-dealkylated lactam of flecainide with little pharmacologicalactivity. Flecainide acetate is given orally to suppresschronic ventricular ectopy and ventricular tachycardia.It has some limitations because of CNS side effects. | | Biological Activity | Open Na + channel blocker that inhibits fast Na + current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent. | | Biochem/physiol Actions | Class IC antiarrhythmic agent; sodium channel blocker | | Clinical Use | #N/A | | Drug interactions | Potentially hazardous interactions with other drugs
Anti-arrhythmics: concentration increased by
amiodarone - halve dose of flecainide; increased
myocardial depression with other anti-arrhythmics.
Antidepressants: concentration increased by
fluoxetine; increased risk of ventricular arrhythmias
with tricyclics.
Antihistamines: increased risk of ventricular
arrhythmias with mizolastine - avoid.
Antihypertensives: increased myocardial depression
and bradycardia with beta-blockers; increased
myocardial depression and asystole with verapamil.
Antimalarials: concentration increased by quinine;
avoid with artemether/lumefantrine.
Antimuscarinics: increased risk of ventricular
arrhythmias with tolterodine.
Antipsychotics: increased risk of ventricular
arrhythmias with antipsychotics that prolong the
QT interval and phenothiazines; increased risk of
arrhythmias with clozapine.
Antivirals: concentration possibly increased by
fosamprenavir, indinavir, lopinavir, ritonavir and
saquinavir, increased risk of ventricular arrhythmias
- avoid; use telaprevir with caution.
Diuretics: increased cardiac toxicity if hypokalaemia
occurs. | | Metabolism | Flecainide is extensively metabolised (subject to genetic
polymorphism), the 2 major metabolites being m-Odealkylated flecainide and m-O-dealkylated lactam of
flecainide, both of which may have some activity. Its
metabolism appears to involve the cytochrome P450
isoenzyme CYP2D6, which shows genetic polymorphism.Flecainide is excreted mainly in the urine, approximately
30% as unchanged drug and the remainder as metabolites.
About 5% is excreted in the faeces. Haemodialysis
removes only about 1% of unchanged flecainide. | | References | 1) Rouet and Ducouret (1994), Use- and concentration-dependent effects of flecainide in guinea pig right ventricular muscle; J. Cardiovasc. Pharmacol.,?24?177
2) Singh?et al. (1984),?The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions; Ann. N.Y. Acad. Sci.,?432?210
3) Banitt?et al.?(1977),?Anti-arrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides; J. Med. Chem.,?20?821
4) Melgari?et al.?(2015),?Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide; J. Mol. Cell. Cardiol.,?86?42 |
| FLECAINIDE ACETATE Preparation Products And Raw materials |
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