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| 4-Methyl-2-(1-piperidinyl)-quinoline Basic information |
| 4-Methyl-2-(1-piperidinyl)-quinoline Chemical Properties |
| Melting point | 72-73 °C | | Boiling point | 177-180 °C(Press: 4.5 Torr) | | density | 1.102±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble5mg/mL at warmed (clear solution) | | form | powder | | pka | 7.34±0.61(Predicted) | | color | white to beige |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| 4-Methyl-2-(1-piperidinyl)-quinoline Usage And Synthesis |
| Description | ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM. | | Uses | 4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation, muscle response due to interaction with the environment. | | Uses | 4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation and muscle response due to interaction with the environment. | | Biochem/physiol Actions | ML204 is a potent and selective TRPC4 channel inhibitor. |
| 4-Methyl-2-(1-piperidinyl)-quinoline Preparation Products And Raw materials |
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