POLYGUANYLIC ACID (5') POTASSIUM SALT

CAS No.：54684-83-2

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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POLYGUANYLIC ACID (5') POTASSIUM SALT Basic information

Product Name:	POLYGUANYLIC ACID (5') POTASSIUM SALT
Synonyms:	POLY[G] POTASSIUM SALT;POLYGUANYLIC ACID (5') POTASSIUM SALT;POLYGUANYLIC ACID POTASSIUM SALT;polyguanylic acid (5') potassium;Polyguanylic acid potassium salt lyophilized powder
CAS:	54684-83-2
MF:	C10H14N5O8P
MW:	363.22
EINECS:
Product Categories:
Mol File:	54684-83-2.mol

POLYGUANYLIC ACID (5') POTASSIUM SALT Chemical Properties

storage temp.	-20°C
form	lyophilized powder

Safety Information

WGK Germany	3
F	3-10-21

MSDS Information

Provider	Language
SigmaAldrich	English

POLYGUANYLIC ACID (5') POTASSIUM SALT Usage And Synthesis

Uses	Polyguanylic acid potassium salt has been used: as a ligand for surface neuropilin-1 (NRP1) for internalization studies for intercalation studies with trisubstituted and disubstituted triazole-linked phenyl derivatives CL41, CL42 and CL2r50 using voltammetry method as a synthetic polynucleotide for agarose gel electrophoresis analysis
General Description	Polyguanylic acid takes up a four-stranded helical structure. It is synthetically produced in Thermus thermophilus from guanosine diphosphate (GDP) and its synthesis is catalyzed by the enzyme polynucleotide phosphorylase.
Biochem/physiol Actions	Polyguanylic acid acts as a ligand for scavenger receptor and reduces the surface expression neuropilin-1 in endothelial cells.

POLYGUANYLIC ACID (5') POTASSIUM SALT Preparation Products And Raw materials

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